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I can second this - my main driver is a Dactyl-Manuform (ortholinear), and I have zero problems on any of the other four non-ortho keyboards that I use.

I also use Dvorak as my main layout and have no problems when going back to a QWERTY one.

I've also been using a Moonlander since late 2020 and going back to a laptop has been fine. The fact that on my two Lenovo laptops, the Ctrl and Fn keys are not in the same order (whoever thought this was a good idea?) is anecdotally also a much more frequent cause of issues.

It is the modifier keys that has me using two magic keyboards like the article. When I'm away from my desk, with my mac, I can still use it.

With a programable mechanical kb you should be able to match the Mac layout. There are a few split versions that should have sufficient keys, especially if you're not using a ten-key frequently.