Switching to ortholinear can really mess you up when you have to use a laptop or colleague's keyboard.
The differently placed modifier keys on the laptops screw me up infinitely more than going from an ortholinear split to a laptop and back.
I also use Dvorak as my main layout and have no problems when going back to a QWERTY one.
Three separate skill sets. But all very learnable.
That said, I don't really want to use normal keyboards anymore. This feels like how computer keyboards should've been designed from the start.