Hacker News Reader

Comment by encryptluks2 | Hacker News Reader

I definitely think that the research indicates MDMA or even microdosing can be beneficial to some people, but we can't even get marijuana removed as a schedule 1 substance... I doubt they'll allow MDMA therapy anytime soon.

View on HN

There was an article about about soldiers and therapy with taking MDMA. The title was something like "Soldiers with PTSD give MDMA rave reviews"

There's also therapy with LSD.

I find that I am primarily frustrated by the uncertainty. It is clear that people independently seek out these substances and we have promising evidence that suggests that this class of drugs has a host of potential beneficial effects to many people.

It then becomes infuriating that a an ideology towards drug control that seems to be universally regarded by informed people to be misguided and causing more harm than simply doing nothing, is still interfering with our collective ability to evaluate these substances in an objective way.

I am skeptical about microdosing on MDMA, as the substance itself is pretty taxing on the body and the brain, and I don't think much good would come from completely depleting your serotonin levels.

I think this substance is useful, but its usage is best kept on a (bi-)monthly basis so you have time to recover between sessions.

A better candidate than MDMA for microdosing with similar effect would be 2-CB. It does not deplete any of your serotonin, and you recover from it in a couple of days, even after massive doses.

>2-CB. It does not deplete any of your serotonin, and you recover from it in a couple of days, even after massive doses.

A couple of days doesn't sound great tbh.

Couple days is typically worst case scenario. I only experienced that once when I wandered a lot during the experience, so it may not be completely imputable to the drug itself.

Last time I used it I stayed comfortably at home. The day after I could go hiking in the Alps without any problem.

Anyway, the tiredness you feel after using 2-CB is nowhere near as close to that you experience with MDMA, which may last for weeks. Which leads me to think 2-CB would be better for microdosing.

Also this is in no way me advocating 2-CB has being completely safe. Most people who tried it deem it so, but as of yet few researches have been conducted on that substance.

Well, considering the alternative is "permanent brain damage", it's nice to know that after a couple of days you would be back to normal.

Do you consider it a superior substance? What would be your favorite activities with it? I heard it's the better than m for raves where you can delve into the energetic, empathetic, as well as more psychedelic nature.

Let’s hope the critics are right and this is a slippery slope. A few more states and a bad economy and pot will be federally legal I think. After that, maybe loosened restrictions on therapy trials?

God, I hope so. Once the US has legalized, Europe can follow. Spoken as someone who maybe vaporizes some once a year and has no trouble sourcing it, but it's such a dumb example of "no, it's been that way and we'll keep it that way" with irrationality turned way up.

Exactly, and it's not even been this way for very long. There's a favourite anecdote where I come from about an old woman tending a rather isolated farm who was quite surprised when the police showed up in force and demanded to know more about her little weed field some time in the 60s or so.

Yeah Marijuana is in weird state and hopefully LSD, MDMA will reach that point too.

There are already Ketamine clinics where I live. I know Ketamine was mot Schedule 1 but I could see it getting approved for therapy within a reasonable timeframe.

Do your own therapy macrodosing MDMA you can buy from under bridges!

I was referring to microdosing LSD or psilocybin, but maybe your sarcasm is just what we need cause that is exactly what people are doing is still obtaining the drugs in an unsafe illegal way. It is common sense IMO opinion to make sure people are informed and safe than creating these black markets by making things like this illegal while for years doctors were overprescribing opiods.

Reply on news.ycombinator.com