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> So if you’re going to give patients an mRNA injection and you don’t want to set off alarm bells in the innate immune system, you’re going to have to carefully engineer your sequences at the very least.

Isn't that what substituting uracil by pseudouridine solves?

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No, that substitution helps, but it doesn't solve the problem. You're still introducing foreign mRNA into the body, and the body still has millions of years of evolution telling it that foreign mRNA = invader .

It solves the TLR problem, and process/purification solves the cytosolic dsRNA problem.

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