Not necessarily a “large scale” problem but the increased salinity means you create a enormous dead zone near your output system unless you spend a ton of energy to mitigate it.
We had Bechtel design us a desalination/RO system for a biofuel startup I worked with and to prevent the dead zone, you need a massive system of buried pipes in the ocean. Iirc, it was the most expensive part of the entire design since you need to output it over something like a square kilometer and you need to mix in fresh seawater at several points to dilute the effluent before you release it. So in addition to the CapEx of a construction project in a horribly hostile environment, you have permanent energy consumption even past the filters.
And of course, since it’s coastal, there are tons of regulations and government bodies interested in making sure you don’t cut corners.