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I am not a biologist by any stretch, but I will try.

A common mechanism of action may have been found across antidepressants where none was found before. This common mechanism between both Prozac and Ketamine has some impacts on how cholesterol is used in the brain and BDNF (neuron survival and growth regulator).

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Thank you - interesting. I wonder if the cholesterol changing mechanism is why some people seem to gain body weight/fat who are on certain medications.

My amateur guess is that because some of these drugs are associated with weight gain and some are not that this mechanism of action is not the primary actor for antidepressants with weight gain side effects.

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