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Comment by loceng | Hacker News Reader

I will read this in full later - though anyone care to reply with a TL;DR for everyone here?

I am not a biologist by any stretch, but I will try.

A common mechanism of action may have been found across antidepressants where none was found before. This common mechanism between both Prozac and Ketamine has some impacts on how cholesterol is used in the brain and BDNF (neuron survival and growth regulator).

Thank you - interesting. I wonder if the cholesterol changing mechanism is why some people seem to gain body weight/fat who are on certain medications.

My amateur guess is that because some of these drugs are associated with weight gain and some are not that this mechanism of action is not the primary actor for antidepressants with weight gain side effects.

It's a short article. Just read it.

I think there's more value in the comment you're replying to than your own comment - I imagine you took the time to downvote too? At least thank you for spending the effort of writing something.

I did not, because I thought enough others had done so already. Asking other people to do your thinking for you is noise, and belongs at the bottom of the thread. It's fine if you can't be bothered to read it right away: HN has a save feature just for that. But don't inflict your laziness on the commons, especially for an article that is so very short.

I think this article was written for a more medically/biologically literate audience than the typical HR member. It assumes a level of jargon and background knowledge. I think it’s reasonable to ask for a summary targeted towards the HR audience.

That would be more reasonable, but it's not what they asked for.

Glad you can at least admit there's value to my question now - maybe you shouldn't assume why someone's asking for something or what their capabilities generally are. In reality I did start reading the beginning of it and it was dense, I didn't check how long it was either, but that's what lead me to coming back to HN and posting. So yes, I see now if I had explained that in full you would have likely had compassion for my asking the question.

I didn't assume. As far as could tell, you said your reason up front. Don't pretend it's my fault for taking you at your word.

I stand corrected.

"But don't inflict your laziness on the commons"

So you must be against the downvote mechanism as it's a lazy, near effortless way for people to get a hit of dopamine vs. your qualitative response that actually shares thoughts that I am more likely to respect and take note of?

No, I'm in favor of the downvote mechanism as a way to sideline noise. I'm only against lazy usage thereof.

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