I have applied to around 100 positions, had three interviews and countless form rejection letters.
I am stuck working remotely or in the city I am in now so understand its been hard but I am just about to the point where I think I will not have a real "career" in my lifetime. I fluctuate between blaming my poor choice in going into the life sciences and the "economy" in general. Between unemployment, food stamps and living at my parents things are going pretty well but have basically given up on finding a meaningful job.