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> The vaccine manufacturers literally had one chance to guess what the right application schedule was, and had one chance to do clinical trials on them.

Couldn't they have done additional arms in the trial? Moderna could have had a trial arm with 1 mcg doses.

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This is what I don't understand... why didn't we run several parallel studies for different dosages and time frames? I highly doubt there was a shortage in the pool of people willing to sacrifice themselves.

Because the trial sizes would need to be similar, so now you’re trialing you recruit 120,000 people across 4 trials.

How long would that delay trial results you think?

Is it a requirement that they end at the same time? I would have volunteered.

No, but in order not to delay your main trial, you’d have to delay recruitment for the others or else your competing against yourself for patients.

And if they just delayed the other dosing arms, we’d be in the same spot we are now anyways - waiting for more data.

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