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Depends - Boston can be cheaper if you don't have a big commute and the public transportation can help. Source: I've lived in both.

Yeah I looked into home prices rent/buy. True that you can find something _cheaper_ but not cheap/good enough to justify the lower salary and less tech opportunities. I came to the conclusion that Boston is just as expensive as SF but with less opportunities.

Philly is supposed to have an _ok_ biotech scene, so I hear.

You can work in biotech in any city on the west coast