I (used to) have to use my laptop a lot (meetings, traveling), so it didn't work for me to have a different keyboard at my desk. Then when I got stuck at home, I dug out my old kinesis but it was just too much effort to press those keys, and the cursor keys were just too far away. I could feel the muscles in my arms complaining.
But the pronation and ulnar deviation was a pain, so I bought another one, so now I can angle them perfectly for each hand. If you want to try it you'll need karibiner [1] so that the cmd keys work across keyboards.
I'm still using the magic mouse because I found click-drag with the trackpad to be shitty. Is there a trick to that?