Sure it does, a language alone isn't much help if it only gets a tiny slice of the ecosystem.
No .NET Native, GUI designers, WCF/gRPC, EF designers, Blend, WinUI tooling, ASP.NET templates,... hinders adoption at corporate level.
No .NET Native, GUI designers, WCF/gRPC, EF designers, Blend, WinUI tooling, ASP.NET templates,... hinders adoption at corporate level.
Ironically, despite .NET core being an excellent runtime, it suffers stigma from being assumed to be too tied to Microsoft platforms. This means, depending on your angle, F# lacking specialized ties to the Windows specific tooling you mention need not be considered a disadvantage.