In prison, the worst punishment you can get is being moved AWAY from all the rapists and murderers, and into solitary confinement. Humans are extremely social creatures.
I still have my job, but not being able to go out and socialize in the evenings and on weekends is driving me a little nutty. Sure, I work on some side projects, read books, work out, watch films, etc., but it just doesn't come remotely close to filling the same void for me as having a drink and good conversation (in real-life) with my close friends, or swinging by my climbing gym, or seeing live music.
I don't think that means something is "really off" with me, or that I'm "domesticated livestock" - it just means my hobbies and the way I like to spend my time aren't as pandemic-friendly as yours.