Author here: I've seen your guides before, they're really great! I'd say my article looks at the difficulties, but also the great benefits malware authors have by writing in Python.

> Packaging with PyInstaller to create a single (but large) executable is easy and helps avoiding detection as the interpreter is embedded in the PE

If you look down further in the article it explores detecting PyInstaller generated executable using simple YARA rules. So, I'd disagree a bit there. I personally think that Nuitka (talked about in the article) in conjunction with a packer would be the best compilation method to use in-order to evade detection. It's actually quite surprising to me that limited malware samples have been seen in the wild using Nuitka, but as the title of the articles states- it's on the rise.