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Comment by whoisjuan | Hacker News Reader

I might be wrong, but I thought any human trial needs at least a full one-year follow-up to make sure that the vaccine didn't cause any damage, side effects, reactions, etc, and that indeed created long term immunity.

It seems to me that rushing the timelines potentially opens up a lot of risks for post-vaccine side effects. Doesn't it?

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That's what the article says, human trials in fall this year and then a regulatory filing a year later. There is basically no chance of a vaccine for this being widely available before 2022. That assumes that one of these vaccines works, despite no vaccine for a coronavirus ever passing regulatory approval (hence this is a hard problem, and plenty of incentive to vaccinate against things like common cold which would be a nice money earner for a someone).

I laugh every time someone telling me we will have something by winter... We will live with quarantine and social distincing for quit for a while.

We might yet have a vaccine in 6 months (optimistically) [0] though 12 to 18 months is much more realistic. Different categories of vaccines have different manufacturing and safety profiles [1] depending on which we a vaccine candidate might be approved sooner than expected, especially since 3 novel, previously untested platforms have made it to clinical trials, already.

[0] Even if shortcuts ... can be found, it is unlikely that a vaccine would be available earlier than 6 months after the initiation of clinical trials. Realistically, SARS-CoV-2 vaccines will not be available for another 12–18 months. From: https://www.cell.com/immunity/fulltext/S1074-7613(20)30120-5...

[1] https://www.cell.com/action/showFullTableHTML?isHtml=true&ta...

There are animal vaccines for coronaviruses that have regulatory approval, just none for humans.

There is zero incentive to make a vaccine for the common cold. Let me introduce you to the multi-tens of billion dollar OTC common cold treatment market.

>I thought any human trial needs at least a full one-year follow-up to make sure ...

Depends what you mean by "need". If you're talking about a risk/benefit calculation for getting a vaccination, I expect it will play out very differently for high-risk elderly folks vs low-risk young adults.

Yes it does. Vaccines can and do cause serious side effects and some can take quite some time to manifest.

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