I wouldn't worry about the spread of level 4/5-automation changing the calculus here on a small actor basis. VBIED's are already a serious threat, and require no significant technical innovation, but outside of conflict zones we don't see a ton of them.
Assuming we don't require physical failsafes though and truly airgap driving systems from any network connectivity (which we won't, I guarantee it) there's definitely a worry on the state level actor front.
I can totally imagine the first salvo in WW3 being the utility grid, cell networks, and crashing all the rooted cars, but that horse has likely already left the stable.