Well yeah, obviously: high risk, high reward. Without the benefit of hindsight (and subsequent tests), a paper that proposes something truly transformative will look a lot like one that is just wrong (albeit, wrong in a creative/novel way). If you want to publish the former, you're going to have to take a lot of risks and publish a lot of duds. Don't we complain all the time that NSF doesn't fund high-risk science?