> Most people live meaningless lives
I don't believe I've ever heard this phrase uttered by someone who wasn't an arrogant prick. Different people find different meaning in their lives. That they don't share the same definition of meaning that you do does not make their lives meaningless. For a lot of people, chasing social and economic status and raising a family absolutely does have meaning for them.
Now, if we're only talking about people who feel empty, well, feeling like your life lacks meaning is kind of the definition.