Most people live meaningless lives, that is why they feel empty. If you're just chasing the next raise or promotion or just raising a family so that they in turn can do the same you will inevitably end up feeling empty, whether you're living by default or not. On the other hand, if you have some goal or passion you are pursuing ( one that you believe to be even more important than yourself) , then you will find yourself in the right city, surrounded by the right people, as a result of that.
I agree with the article for the most part but I think it's missing a big piece as far as suggesting _what_ should be driving all these "default" people to change.