There is no such thing as one drug which makes all other drugs redundant.
Disulfiram (brandname Antabus(e)) works well for alcohol addiction. Methadone for heroin addiction. Bupropion (brandname Zyban) for smoking cessation.
As for DMT + MAOI (which I know as Ayahuasca), care should be taken when using a MAOI. Most importantly it must not be combined with a plethora of other drugs and foods, but there are some additional sharp edges to take into account beyond that.
I've only used Ayahuasca once recreationally. It was the most interesting experience, compared to Psilocybin. They say that with MDMA, only your first experience is magic. I've used it approx 10 times, and can attest to that.
I do not recommend everyone should use this or any other drug once in their life. From the drugs you mentioned, there's one which you didn't which is relatively mild, safe, and that is Muscimol (found in A. Muscaria aka fly agaric).
My advice is very simple and universal (caveat [1]): go to your doctor instead of recreationally using drugs, and exhaust all options there. It was then, through rough milling and various therapists, that I found out that I have ASD. Which explained far, far more than any recreational drug usage I've had. And I have had my take as the above might suggest. Of all the drugs I have used, I feel marihuana was the most dangerous one because I had multiple psychoses on that one.
[1] Though I do realise not everyone in the world has access to quality, affordable healthcare