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Comment by simonsaidit | Hacker News Reader

Mushrooms, mdma, lsd, ketamine are often praises as therapeutic but I’ve had close relations with all of them and been in a culture where that belief is there and seen so many scenarios it’s unbelievable. Yes they might have a short lived effect but they are incredibly hard to manage. I advise everyone to try once in their life but keep it at that and try to use the effect for something... which might be the hard part. Today the only drug I believe is fairly safe and has a much harder effect is Changa(dmt + Maoi) which might end the need for all other drugs and help stress or bad thoughts Which it had to me and over 70 people I took through it.

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> which might end the need for all other drugs

There is no such thing as one drug which makes all other drugs redundant.

Disulfiram (brandname Antabus(e)) works well for alcohol addiction. Methadone for heroin addiction. Bupropion (brandname Zyban) for smoking cessation.

As for DMT + MAOI (which I know as Ayahuasca), care should be taken when using a MAOI. Most importantly it must not be combined with a plethora of other drugs and foods, but there are some additional sharp edges to take into account beyond that.

I've only used Ayahuasca once recreationally. It was the most interesting experience, compared to Psilocybin. They say that with MDMA, only your first experience is magic. I've used it approx 10 times, and can attest to that.

I do not recommend everyone should use this or any other drug once in their life. From the drugs you mentioned, there's one which you didn't which is relatively mild, safe, and that is Muscimol (found in A. Muscaria aka fly agaric).

My advice is very simple and universal (caveat [1]): go to your doctor instead of recreationally using drugs, and exhaust all options there. It was then, through rough milling and various therapists, that I found out that I have ASD. Which explained far, far more than any recreational drug usage I've had. And I have had my take as the above might suggest. Of all the drugs I have used, I feel marihuana was the most dangerous one because I had multiple psychoses on that one.

[1] Though I do realise not everyone in the world has access to quality, affordable healthcare

> They say that with MDMA, only your first experience is magic. I've used it approx 10 times, and can attest to that.

My first time was fairly meh, but one of the last times I took it, after a multi-year break, was pretty magical.

Changa is much more intense but t less a strain on the body. Changa is smoked and doesn’t work the same way although benefits are similar to ayahuasca but no you do not risk cheese syndrome from the Maoi in the same way as ingested. The literature is not big on the subject yet but dig and you will find. My advice is uppersit stay away from most doctors or atleast research what they are trying to do to you. Seen a lot of life’s ruined by them sadly. And yes Changa is so strong you probably won’t feel the need for any cravings a while alcohol sugar coffe weed and whatever doesn’t mean much on top of this experience which you can probably live on the next 40 years. I don’t get my ideas from only reading but first hand experience. Myself quit 15 years of daily weed abuse from one day to the other. I don’t feel a need for any substances anymore. Lots of people did similar after one and only one trip of 1 hour. Worked with alcohol and weed and stress and being an idiot from my experience. It’s easy to go back to bad habbits but with this it’s also easy not to. It’s about the mindset you ned in not the body’s reaction which will ofcourse be there a while. And cook your own Changa the one you buy don’t have enough active alkaloids and is made for profit.

> Today the only drug I believe is fairly safe and has a much harder effect is Changa(dmt + Maoi)

Erm, sorry, but I'm really not sure the words 'safe' and 'maoi' should be in the same sentence there. There are a lot of precautions one needs to take to make sure you don't end up with severe hypertension and requiring a trip to an emergency room.

I think we should probably take the outcomes and evidence of the ongoing scientific research, for what is safe or not.

To my understanding, MAOIs only pose a hypertension risk in combination with stimulants like tyramine, caffeine, amphetamine and derivatives, etc. DMT isn't a stimulant.

Also, hypertension risks are generally a problem for MAOI prescriptions: people who take MAOIs every day. With DMT, a MAOI is only consumed once, with the DMT. DMT is rarely taken on a regular and frequent basis, so it's unlikely someone would be consuming a very risky quantity of MAOIs over the long term.

MAOIs may increase DMT risk in other ways, but I don't believe hypertensive crisis is an issue for that specific combination.

> To my understanding, MAOIs only pose a hypertension risk in combination with stimulants like tyramine, caffeine, amphetamine and derivatives, etc

They pose a risk with alcohol and lots of different foodstuffs too - https://www.mayoclinic.org/diseases-conditions/depression/ex...

> MAOIs may increase DMT risk in other ways, but I don't believe hypertensive crisis is an issue for that specific combination.

Not with DMT itself, but if taking an MAOI at all you need to take a lot of precautions (fasting, avoiding certain foods and drink etc) to avoid the possibility.

It's manageable, clearly, but just blanket saying not only that it's fairly safe, but that it's the only fairly safe drug disregards the specific risks associated with MAOI use over and above those presented by (for instance) LSD or MDMA.

All those precautions is when you ingest it. Research.

I actually had a bunch of caveats like those in my original comment, but edited them out because I felt like they were unnecessary. Yes, MAOIs definitely shouldn't be taken in combination with foods or beverages or substances which are contraindicated for it, but that's mostly an issue for "non-selective" MAOIs, and is unlikely to affect someone who only takes a single MAOI dose once per year.

I just meant DMT isn't known to pose a particular risk when combined with a MAOI, unlike taking a MAOI with amphetamine or something. Obviously people should research what they should and shouldn't take with them.

People don’t know much about the subject Maoi smoked and ingested works differently. I’m fine relying on my 20 years of personal experiences and the little literature there is on the subject.

You probably shouldn't be advising people that it's the only safe drug. That's all. MAOI use presents risks that are not found with other drugs, so it requires as much or more care and attention to be safe.

But in the case of this maoi Which is different than found in Pharma.. a vs b. in the way it Works smoked vs ingested there is No evidence it should cause harm. Its Been used for centuries. I have enough experience to say that most recretionaæ drugs are unsafe and i do not put changa in this catagory. Most people here just talk about What they read.

If they read good science, I'd put that above your anecdotes every time.

Many things have been used for centuries, including Belladonna. Doesn't mean a lot

A ten second google search will show you examples of people who have had this side effect from "Changa".

Care to share this finding. I worked at festivals with 40k people doing everything u can imagine and have yet to come cross anyone. I’ve seen people die or ruin their life from most drugs including ordinary pharma apart from dmt and Changa which is always described as life changing best experience ever.

MDMA is by no means harder to manage than DMT. 100mg with some friends in the couch and 99.9% of people is going to have a blast and will look back at it as an experience that was really worth having, probably with some lasting insights.

The DMT experience is not something for everyone. Adding a MAOI makes it more dangerous physically.

No there is no evidence of anyone having cheese syndrome by smoking. It’s for oral and it works differently there.

The therapeutic dose for ketamine is far lower than the recreational dose. (I don't know anything about the others.)

What it the suggested clinical dose for ketamine for a user with no tolerance?

Also what would be a recreational ketamine dose? As ketamine is almost like two separate drugs at the dosage spectrum. From a small bump to get a bit floaty / wobbly all the way to deep immobile kholes

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