I ended up missing weddings and job opportunities because the fear of flying was so intense.
I now fly regularly, and without issue. It took a long time, but I've found a few things that worked for me:
1. No caffeine on a flight day. This helps for any anxiety that may start to build for me.
2. Noise cancelling head phones w/ ear plugs. A lot of my anxiety came from paying attention to the sound of engines. Was something odd happening? Keeping the sound of the engine drowned out helped keep my mind off the mechanics of the airplane.
3. Neck pillow / comfortable clothing. Being warm and comfortable lets me fall asleep, completely avoiding any anxiety that may have otherwise come.
4. Timing flights to avoid common storm times. I'm in Florida, and the afternoon thunderstorms can be extreme. If I can, I try to fly out early in the morning, or late at night when the storms tend to not occur.