When my SO is out of town, my brain generates all sorts of horrible possibilities of things that could happen to my while laying in bed, from simple home invasions to black holes suddenly appearing and consuming my right arm. Watching Futurama (I had no idea there was a whole community around it) distracts me from those invasive thoughts.
While I work I need some noise, something, nearly anything. The complete lack of silence bothers me. I usually listen to OCRemix at work (via rainwave.cc) or 90's/00's music from when I was younger (nostalgia).
At home I will put on something like Friends (Netflix), Giant Bomb videos (giantbomb.com), or classic game play throughs (NES, SNES, Genesis) on YouTube (or Giant Bomb). For example, LaserTime did Aladdin SNES vs Aladdin Genesis side by side video and they played through NES Teenage Mutant Ninja Turtles and The Simpson's games on NES/SNES. Giant Bomb has a series called Vinnyvania where Vinny (one of the Giant Bomb employees) plays through all the Castlevania games and another where they play through all the fighting games and rank them. I'm not into the new games.