This post explains it: https://news.ycombinator.com/item?id=12282894

TL;DR: modern email providers don't care if you are in blacklists. If your IP/domain does not have established reputation, they will drop half of your email in spam folder. If users whitelist it or reply to it, your reputation automatically improves.

If your send too much email or your receivers blacklist you (delete without reading or manually move your email to spam), your reputation takes nose dive. Some providers (for example, Yandex) openly describe that logic in their FAQs.