How does AB testing and user profiles have anything at all to do with detecting when incoming email is spam?
TL;DR: modern email providers don't care if you are in blacklists. If your IP/domain does not have established reputation, they will drop half of your email in spam folder. If users whitelist it or reply to it, your reputation automatically improves.
If your send too much email or your receivers blacklist you (delete without reading or manually move your email to spam), your reputation takes nose dive. Some providers (for example, Yandex) openly describe that logic in their FAQs.
However, as someone who uses SpamAssassin (via FastMail), spam clearinghouses like Spamhaus are still very important. And as long as we want to avoid centralizing all email in the hands of a few massive providers, they will continue to be important.
(I just wish there was better documentation of what all the rules mean, and how to satisfy them.)