Human minds aren't good with very large numbers. What seems "practically infinite" to us - isn't, really.
The number of all planets in the universe is said to be in the ballpark of 10^24.
Meaning (obviously) if you keep on dividing it by 10, in just 24 steps you get down to 1.
Meaning if there are 24 factors crucial for life to evolve, and each has a 10% chance of occurring - it's actually quite likely only one planet would win on this lottery. (At a given point in time, that is - that's another aspect of course).
Or 12 factors, but each with a 1% chance. And suddenly it doesn't seem like a number big enough to warrant certainty claims...
Basically it is the "wheat and chessboard" problem in reverse.
You start with a huge pile of planets, but once you start splitting the pile, it shrinks very very fast.
Personally I'm not sure either way, and I think being sure (either way) is just naive.
I believe there is microbial life out there, and I accept a slim chance we may actually discover it - say, over the course of the next few centuries - but I'm sceptical about the existence of intelligent life, and even if it did exist, I see the chances of any contact to ever occur as zero.