That's entire galaxies. Not just stars, and that's just the observable universe.
We are still being surprised by the lifeforms we observe here on Earth, and the environments and conditions they can thrive in (including the outer hulls of our spacecraft), and we still have yet to discover and catalog all the life on our planet. Life may even come in the form of "artificial" constructs that build, learn, teach and reproduce on their own, created by "natural" life somewhere then set free into the cosmos.
How, when given the evidence of practically infinite planets out there (considering that almost every star may have at least one planet, and there are even rogue planets [0] that don't orbit any star, and that asteroids and comets or even dense nebulas could also harbor life), can we even consider the possibility that this is the only planet with life?
This game is Big, folks: Even if 90% of all planets had life there would still be billions if not trillions of them without any life, and the incomprehensibly vast distances (including voids, like the one our own galaxy is near or inside of [1]) between them may mean millions of years before life from one planet encounters life from another (which is good I suppose; every species would have some room to expand into at their own pace.)
And of course, not all intelligent civilizations will be "successful."
We will either die out on our home planet or expand.
We may not encounter other life for hundreds or even thousands of year after we develop interstellar travel, or the life that we encounter may turn out to be mundane and eventually unexciting (I mean, imagine being an spacefaring species discovering us; planetlocked and still collectively figuring many basic things out.)