I worked at a print shop that switched from DOS to Windows for it's POS software, it was an order of magnitude slower. At least we could play solitaire though.
Presumably this is it. I find typing on numpad is much faster and simpler, but 1) laptops typically don't have one and 2) on normal keyboards it takes my hands away from the main keyboard. Then I switched to a Kinesis Advantage2 and now the numpad is integrated into the main keyboard, using a foot pedal to toggle between main keys and integrated keys.
In PoS, you're not likely to be typing many letters most of the time, so left hand for function keys, right hand for numbers is pretty good. You can move your hands if you move to a search.
For POS and similar applications it actually makes sense to design the UI such that it can be used only with numpad, for example by using +,-,*,/ as function keys for common operations.