Source: I bought a house in one of these neighborhoods recently because it was so cheap. While there was absolutely nothing near me to do, going downtown still only took 15 minutes, so I had absolutely no problem with life there. I had my silence and my work-from-home office in my comedically large, cheap house and then if I wanted to catch a show or get dinner I would hop in the car and go downtown to meet up with friends.
I actually live in Boston now and am paying twice as much as my mortgage for a third of the space. Not an exaggeration. And it actually takes me twice as long to get out and do some things because Boston is so congested with traffic. Sadly, I think by the time I ever return to Austin, I'm sure it will have seen enough growth that it will be much the same cost to get culture from my suburban house.