Source: I bought a house in one of these neighborhoods recently because it was so cheap. While there was absolutely nothing near me to do, going downtown still only took 15 minutes, so I had absolutely no problem with life there. I had my silence and my work-from-home office in my comedically large, cheap house and then if I wanted to catch a show or get dinner I would hop in the car and go downtown to meet up with friends.
I actually live in Boston now and am paying twice as much as my mortgage for a third of the space. Not an exaggeration. And it actually takes me twice as long to get out and do some things because Boston is so congested with traffic. Sadly, I think by the time I ever return to Austin, I'm sure it will have seen enough growth that it will be much the same cost to get culture from my suburban house.
I would find it very hard not to have a supermarket or a corner shop nearby for when I run out of this or that and it isn't time for the weekly shopping. And I would think it's an excellent small business opportunity.
For others that have existed for longer, sometimes the zoning seems to just be residential forever so sometimes you have to drive for a bit to get to the nearest "stuff". I think that's pretty standard for suburbia.
And then for yet others sometimes they're just too far out and too small of developments to make building a supermarket just for them financially viable.