I gave up tweeting entirely. I have 6 followers and only 3 of them are people I know in real life, however none of them tweet. So twitter isn't a text messaging replacement for me.
I just accepted that Facebook is a much better place for me to put a thought and get feedback from people I know.
I follow ~150 people. The main blobs are pros in a video game I play seriously, and politics professionals, and science/tech professionals, and media outlets.
I don't follow any celebrities or people who I think are just brand pushers.
Now every time I go to twitter I know that I will have a new set of interesting content to pursue. New conversations about strategies or video archives from the game universe. Breaking news with commentary by politics minds I care about (no hacks or rank partisans). Interesting science and tech links from other like minded people who are keeping up.
The real problem with twitter is that it is completely nonobvious how I eventually came to like it. I couldn't ever tell someone else how to curate a set of follows which will engage them. Seems like twitter can't either.