I'm someone who graduated with a non-cs engineering degree (and worked professionally as an engineer) whose now in a MSCS program after trying my hand in the job market. Not for a lack of trying, but my experiences definitely relate to an uphill struggle just to get even noticed. And before anyone says "you should do x|y|z", I've done my part pretty well. A few decent sized personal projects, constant studying, meetups, networking, github, etc.

I hear a lot of anecdotal evidence (mostly from professional devs who have degrees) that they know a friend or coworker who doesn't have a degree.

The truth is that the system for recruiting and hiring is really based around colleges, students, and degree holders. Starting from the application requirements, you see that most applications require a CS degree (or equivalent). Then the technical interview is aimed at fundamental CS questions, most of which students are accustomed to.

So for someone self taught, face to face interactions are a lot better. But even going to events/meetups, you notice a distinct change in demeanor of the recruiter when you mention you don't have a CS degree. It really is a tiring battle just to prove that you're competent.

Do I believe that you 100% need a degree to get a CS job? Definitely not. But without one, your options are very limited and on top of that you'll need a lot of luck and effort just to get past the first hurdle.