My escitalopram comes in 5mg, 10mg and 20mg. If I want to slowly taper down from 20mg a day, I have to start chopping off bits from an already tiny pill every day for months on end. I can't just drop down to 15mg a day, it's too abrupt.
> Most regulators worldwide have decided that a 20% variation is generally not clinically significant.
>Two versions of a drug are generally said to be bioequivalent if the 90% confidence intervals for the ratios of the geometric means (brand vs. generic) of the AUC and Cmax fall within 80% and 125%. The tmax (brand vs. generic) must also be comparable — and there should not be any significant differences between different patients.
[1]https://www.sciencebasedmedicine.org/generic-drugs-are-they-...
[2](cmax, auc, graph comparison) http://www.bpac.org.nz/BPJ/2007/March/bioequiv.aspx