4,079 karma · joined August 20, 2014
Personal opinion, when intra org reciprocity is not discussed or measured, quality plummets as a necessary response to stress/burnout feedback loops at every scale.
Coming to terms with this """insight""" etc. was tl;dr life changing and exactly how is still an open question
> It would be SO cool if there was a drug that gave me this ability but didn't make me "high" or confused in the way weed or shrooms do.
On one hand, with enough practice and skill in doing drugs the "confusion" and maybe even "high" will go away, and become just more ordinary sensations
On the other hand, the drugs are certainly helpful for developing faith that it is possible to "get there", but they're not so great at "how to get there from here" (unless you're already well practiced at looking). Kind of like sleeping in the taxi to the top of a mountain versus walking up it.
Under the "travel" metaphor, I guess training in doing drugs would be training "how to get back here from there", while training Concentration alone would be training "how to get there from here". The latter is certainly more effort up front. Some people find the former to be more effort later on, unfortunately. The latter is also attractive for other reasons which should be obvious (it's free)
funnily enough I have a team reverse engineering binary data formats, which is often more easily accomplished by other means + only dropping down to the disassembly/decompilation where absolutely necessary. and which as far as I am aware never involves binary patching
but yeah about the article it seems like if you know this much about assembly / chips etc. to be able to read it, then general problem solving ability should be able to cover most of the article's content
It would be surprising if one's body were different. The general level of faith there seems inconsistent with reality
> Our first test doses
implying there were more later
I'm genuinely ... horrified, impressed, and much more.
The product booklet in revolution / frontline rx is actually really comprehensive and worth a read here, it goes in to the pharmacology in detail.
... In spite of all this I still do poison my cat's bugs but try to pad the dosing schedule by a week or 2 each time, it's not like the life cycle of the critical parasites is longer than that.
[0] mostly glutamate gated chloride channel activators, and mammals don't have these receptors. but mammals do have glutamate gated cation channels (AMPAs/NMDAr) and the drugs bind activate them too, just only a little tiny bit... that adds up in an overdose. What you get from excitatory glutamate channel activation is seizures.
> A city slicker shoots a duck out in the country. As he's retrieving it, a farmer walks up and stops him, claiming that since the duck is on his farm, it technically belongs to him. After minutes of arguing, the farmer proposes they settle the matter "country style."
> "What's country style?" asks the city boy.
> "Out here in the country," the farmer says: "when two fellers have a dispute, one feller kicks the other one in the balls as hard as he can. Then that feller, why, he kicks the first one as hard as he can. And so forth. Last man standin' wins the dispute."
> Warily the city boy agrees and prepares himself. The farmer hauls off and kicks him in the groin with all his might. The city boy falls to the ground in the most intense pain he's ever felt, crying like a baby and rolling around on the ground. Finally he staggers to his feet and says: "All right, n-now it's–it's m-my turn."
> The farmer grins: "Forget it, you win. Keep the duck."
But it can have its utility too, it's just more "defense from morons" instead "advancing the field". Or more neutrally filling in very predictable gaps in knowledge, like if you got something really unexpected but this stuff is all bog standard unhappy cells
I only really considered this after encountering "Deserter: The Last Untold Story of the Second World War" by Charles Glass in a used bookstore, which is appropriately referenced etc.
[1] But what is desertion, really? A legal matter the facts of which are decided through process...
[1] like, Catch-22 was actually toned down from reality so to speak, yes it's technically written by a Korean war vet but
Take for example the dismissal that "waves are just a concept/model/way of describing the universe that is useful and pretty accurate for many purposes".
Yes, this is true, but the wonder is to be found in the universe, not in the model, and the model provides a path to that wonder to be found approaching true understanding. Understanding with one may practically profit, and idk motivational salience to see connections where they are present.
Like, if you stop and think about it, isn't it like totally nuts that light, "heat", "electricity", etc. just smear out into one another at the right frequency, and that you can predict it? That you can ring all the nuclei in a human's body just like ringing a bell, listen to the tone, and turn that into a like a 3d image of tumors and crap? [1] And, this beauty / intricacy / whatever collides into the need to eat and clean up poop and so forth [2] -- And we end up with microwave ovens used thrice daily until broken and trashed, and relegate the concepts themselves into "just"s, because they are ordinary.
And if this sense of holistic appreciation for the universe is more cultivated in more people we'd see more cool stuff or live in a better world or something.
[0] idk, helping the reader develop a sense of ... awe, better intuitive understanding (because people have it no matter how wrong), connection, higher order consequences, all embedded in a practical context or something.
[1] NMR/MRI more or less
[2] which are also emergent consequences of all these heady abstract concepts btw, like what is is that we need to eat, why do we need to eat to begin with, etc.
Which means going to a different layer / structural solution maybe. How does the value of data go to zero?
[0] gently bash someone on the head for decades, cut out their brain, notice it's all shrunken and weird in composition ... maybe in a culture with strong warrior and ritual cannibalism practices
* Corrosive
* Heavy
* Does not lubricate
* Huge heat capacity, i.e. you get cooked if even a little bit of it gets on you)
About the only advantage it has is being cheap, available, and nontoxic which is cool for factories built on riversI mean in this is one model and typically a "result" means several models are all consistent with the researcher's mental model of the thing. But yes, the forced swim test is one measure of "will to live" and it's treated as that because of similarities to "that which we call 'depression'" or whatever
It is better than nothing, unless one takes it too seriously.
[0] mice float, they don't drown when they give up, assuming you take them out quickly enough [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401172/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353513/
As a (recovered, former) neurobio phd it seems the "grasp" is mostly there + the clarity you want just doesn't exist here
I.e., the concept of "depression" is pretty hard to nail down quantitatively in the first place: The best model we've got is a kind of self-contained proven-by-internal-self-consistency thing bootstrapped from questionnaires, which is of course further abstracted away onto those model systems we're allowed to kill: For example, calling "how long do mice swim before giving up if you chuck them into a tank of water" is roughly equated to "amount of depression" (this is oversimplified a bit; you correlate a bunch of those measures etc. but still a lot of very weak signals). Even "relevant quantitative data" like fMRI / ECoG is bootstrapped from questionnaires when it's something undefinable like "depression"
Which isn't the end of the world, everything started out like this, it just sucks when people take these results too seriously or infer too much from them.
And even the human black-box stuff in the DSM manuals admits a lot of different subtypes, lots of different and sometimes opposite symptom clusters, etc. It is entirely possible that mechanistically "depression" is a diverse group of mechanisms all boxed up into the most familiar mainstream concept/word.