HNHacker News
TopNewBestAskShowJobs

wordglyph

229 karma · joined December 7, 2024

Https://wordglyph.xyz
submissionscomments
wordglyph··on Show HN: I built a dual crossword puzzle where two crosswords share one grid
Nice job! I just recently coded my word game into an app of your on desktop you can still play it. Wordglyph.xyz
wordglyph··on Show HN: Email for AI Agents
are your mail servers whitelisted with the big players.
wordglyph··on Show HN: s@: decentralized social networking over static sites
have you considered Replace X25519 with a post quantum cryptography key encapsulation mechanism like kyber or saber?
wordglyph··on Show HN: I built a sub-500ms latency voice agent from scratch
What do you think about https://app.sesame.com/
wordglyph··on I pitched a roller coaster to Disneyland at age 10 in 1978
Good insight. Yes, I do remember at the time, purposely thinking I must lead with my age knowing instinctively that somehow that would help me and they would be more likely to pay attention.
wordglyph··on Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows
You do realize they already are investigating, right? Even looking into MS and parkinson. ALZHEIMER’S DISEASE (AD) and AD DEMENTIA Umbrella review (systematic reviews of SRs): https://www.nature.com/articles/s44400-025-00048-6

Systematic review + meta-analysis (basal microbiota; AD): https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002... https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/

Replicated case-control + functional metagenomics (AD dementia): https://alz-journals.onlinelibrary.wiley.com/doi/full/10.100...

Large-cohort metagenomics (stage-specific / early pathology signals): https://pubmed.ncbi.nlm.nih.gov/40164697

Mendelian randomization (AD): https://pubmed.ncbi.nlm.nih.gov/38788075/ https://www.sciencedirect.com/science/article/pii/S227458072... https://pubmed.ncbi.nlm.nih.gov/40665707/ https://journals.sagepub.com/doi/10.1177/25424823261422629 https://www.medrxiv.org/content/10.1101/2025.08.20.25333769v...

Narrative / mechanisms (useful synthesis, not primary causal proof): https://www.sciencedirect.com/science/article/abs/pii/S15681...

MILD COGNITIVE IMPAIRMENT (MCI) / DEMENTIA (cognition-focused evidence) Systematic review (MCI or Alzheimer’s dementia; PRISMA, PROSPERO): https://www.mdpi.com/2035-8377/17/10/155 https://pubmed.ncbi.nlm.nih.gov/41149776/

Scoping review (MCI and AD gut microbiomes + interventions, through Feb 2023): https://pmc.ncbi.nlm.nih.gov/articles/PMC12825029/

Systematic review of microbiota-targeted interventions for cognition/dementia risk: https://www.sciencedirect.com/science/article/pii/S027153172...

RCT-focused systematic review/meta-analysis of probiotics for cognitive impairment risk/AD/MCI: https://pmc.ncbi.nlm.nih.gov/articles/PMC12645680/

FMT in dementia/MCI context (review of effects across neuro cohorts): https://www.sciencedirect.com/science/article/pii/S266635462...

MULTIPLE SCLEROSIS (MS) Microbiome signatures via global data integration / ML: https://pmc.ncbi.nlm.nih.gov/articles/PMC12383397/

Systematic review/meta-analysis of probiotics in MS (preclinical + clinical): https://journals.plos.org/plosone/article?id=10.1371/journal...

Systematic review + meta-analysis (antimicrobial exposure and MS risk; microbiome-disruption relevant): https://www.sciencedirect.com/science/article/abs/pii/S22110...

Mendelian randomization (gut microbiota causally linked to MS): https://pubmed.ncbi.nlm.nih.gov/39065244/ https://www.mdpi.com/2076-2607/12/7/1476

Broad MS gut dysbiosis and therapeutic modulation review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12668904/

MS gut-brain-barrier and intestinal barrier review: https://www.frontiersin.org/journals/immunology/articles/10....

Example MS cohort biomarker/signature work: https://www.nature.com/articles/s41598-024-64369-x https://www.nature.com/articles/s41598-025-19998-1

PARKINSON’S DISEASE (PD) Multi-cohort metagenomic meta-analysis (Nat Commun, 2025): https://www.nature.com/articles/s41467-025-56829-3 https://pubmed.ncbi.nlm.nih.gov/40335465/

Large metagenomics cohort (Nat Commun, 2022): https://www.nature.com/articles/s41467-022-34667-x

Integrated multi-cohort gut metagenome (Movement Disorders, 2023): https://pubmed.ncbi.nlm.nih.gov/36691982/ https://movementdisorders.onlinelibrary.wiley.com/doi/10.100...

Metagenomic analysis (Movement Disorders, 2024): https://pubmed.ncbi.nlm.nih.gov/39192744/

PD causal-inference and MR discussion (review-type synthesis): https://pmc.ncbi.nlm.nih.gov/articles/PMC12512240/

MR study example (PD gut microbiota): https://journals.lww.com/md-journal/fulltext/2025/10310/caus...

wordglyph··on Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows
Your gut bacteria is the prevention and the cure.
wordglyph··on I pitched a roller coaster to Disneyland at age 10 in 1978
He sent the letter in April 1979! He was only 3 months into the job.
wordglyph··on I pitched a roller coaster to Disneyland at age 10 in 1978
Note to self. Build time machine and fix this.
wordglyph··on I pitched a roller coaster to Disneyland at age 10 in 1978
That's amazing!
wordglyph··on Show HN: I Made Something Weird
Is any content generated by ai?
wordglyph··on Show HN: I've been using AI to analyze every supplement on the market
This is fantastic! I've been doing this manually for years. My main focus is always what does the research show about xyz supplement on gut bacteria.
wordglyph··on Show HN: AI background remover that runs 100% in the browser
Removal worked well but it always downloads a white background no matter if I chose transparent
wordglyph··on Show HN: PDFClear – Browser-based PDF tools with local AI (WASM+Transformers.js)
Integrating AI browser stuff is very cool!
wordglyph··on Show HN: My Light & Spirit – A Clever Indie Puzzle Where Light Becomes Your Tool
Are you planing to make a web version for mobile?
wordglyph··on Show HN: 3D Rubik's Cube Speed Cubing in the Browser
It be fun it you could swipe the rows in the direction you want on mobile
wordglyph··on Show HN: I built a puzzle game that combines 3 Tiles and Block Puzzle
Fun! How do you turn off the sound? And you like challenging word games then check out my game https://wordGlyph.xyz
wordglyph··on Show HN: Built a chess Agent to analyze your games and visualize tactics
It requires email and payment info to get free trial.
wordglyph··on Show HN: I built a free VPN that runs directly in Chrome
Is this running thru your own servers you control? What country are they based in? What is the pricing after 15min? And what methods of payments do you accept?
wordglyph··on Neural audio codecs: how to get audio into LLMs
I used aistudio and it understood pitch and and even emotion with an uploaded mp3
wordglyph··on Show HN: Tiled Words, a daily word puzzle game
Oooh I like that spin action! Well done! Do you play https://wordGlyph.xyz
wordglyph··on Show HN: I invented a new generative model and got accepted to ICLR
Amazing! So basically the statistical LLM concept for imaging.
wordglyph··on Show HN: 100% free static site hosting for you with custom subdomains
This is great! Especially the password.
wordglyph··on Show HN: Quad – A Daily Tile Puzzle
Thank you so much!! I've been working on porting the code to react native expo for an iOS and Android app for the last couple months. It's so much work.
wordglyph··on Show HN: Quad – A Daily Tile Puzzle
Excellent work! Https://wordGlyph.xyz came to me in a dream too!
wordglyph··on Show HN: I solved my movie night headache
See if you can tie it into https://gandalf.network/ or build something similar cause then it would have a better idea of what the user likes and what they've already seen.
wordglyph··on Brutalita Sans: An Experimental Font and Font Editor
This would have come in handy when I built https://WordGlyph.xyz a word game based on building a letter font
wordglyph··on Show HN: Twilio made SMS complicated. We made it 5-minute simple
Am I reading the pricing right? Your intro pricing is 11 cents per sms. Twilio is at .008 cents.
wordglyph··on Show HN: Detect paid Cloudflare plans on any website via ECH
My site https://wordglyph.xyz came back undetermined
wordglyph··on Show HN: I Built a Free Site for Students to Test Their Knowledge on Their Notes
Does that have features notebookLLM doesn't have?
Page 1 of 3Next →