A small update here: another replication using a different CPU, the 6502. In this case, replicators emerge 100 times less frequently than in Z80, due to a lacking LDIR-like instruction
185 karma · joined December 2, 2022
In that previous paper you cite (by the same group) they tested several substrates for spontaneous replication (BFF, Forth, SUBLEQ, and emulated real CPUs. Z80 and 8080 CPU exps confirmed the rise of self-replicators, with the Z80 notably exhibiting multiple waves of increasingly capable self-replicators.
And the instruction set seems quite appropriate for the experiment: Z80 has native block-copying instructions, while it doesn't have MUL, so the task of evaluating polynomials is somewhat more challenging
Not very promising, though.