Hacker News Reader

tusimion There's a spike in Bitcoin activity around the time foreign aid money goes out

"Within the crypto ecosystem, mixers gain relative to both payment processors and ordinary exchanges after disbursement, isolating increased demand for privacy rather than a broad post-aid expansion in crypto activity."

tusimion Plunging test scores are a slow-moving catastrophe

why leave out intermediate years that show the rise before the fall?

    Group                          1998 NAEP  2013 NAEP  2024 NAEP  Change 98–13  Change 98–24  Change 13–24
    -----------------------------  ---------  ---------  ---------  ------------  ------------  ------------
    White                                268        275        266            +6            −2            −9
    Black                                242        250        243            +8            +1            −7
    Hispanic                             241        255        245           +13            +3           −10
    Asian/Pacific Islander               261        279        280           +18           +18            +1
    All public-school students           261        266        257            +5            −4            −9

tusimion Euler's Eyes

sounds like someone pointed claude at a wikipedia page

tusimion AlphaGenome maps 9B DNA variants

google PR machine on relatively low-impact science goin pretty hard

tusimion Prime Gaps at Most 186

who knew the primary utility of pure math would be to juice pre-ipo valuations ¯\_(ツ)_/¯

tusimion Claude Fable 5.1 and Claude Mythos 5.1

aaaaand its blocked from doing even basic tasks in biotech...

tusimion We don't search databases–we calculate reality. EXXOGEN is now live

We have DESRES at home

tusimion Aspirin reverses diet-driven depression-like behavior

all the time. lack of appropriate/translatable preclinical models is one of the largest barriers to new meds. in practice, if you can't find a mouse that has the same disease its almost impossible to prove your cure works,, even if it would in humans

tusimion The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold

"In November 2024, preliminary results of CASP16 showed AlphaFold 3-based models did not significantly outperform older methods for predicting protein-ligand interactions. The top performing models in the CASP16 Pose Prediction for Pharma Targets section were ClusPro[13] and CoDock[14] utilizing AlphaFold 2 based predictions, human visual inspection, and manual adjustments.[15]

In April 2025 Isomorphic Labs raised $600 Million in its first ever external funding round, led by Thrive Capital.[16][17]"

https://en.wikipedia.org/wiki/Isomorphic_Labs

tusimion Tesla is recalling its cheaper Cybertruck because the wheels might fall off

"All 173 of the RWD Cybertrucks sold by Tesla are being recalled"

173...

tusimion Zed 1.0

This is not an official Notepad++ release. It’s an unauthorized project misusing the Notepad++ trademark.

https://notepad-plus-plus.org/news/npp-trademark-infringemen...