tsol

Ketamine is diverted from official sources, usually where it is produced(India, Denmark are common). It's not worth it to make in a lab given how plentiful it is. Its everywhere, in every city. He probably has a guy that gets it online. You can easily buy ounces on darknet markets. I don't recommend you do this-- I just find it interesting how this stuff is all going on as a second blackmarket economy in absolutely huge quantities.

Military and intelligence contractor stuff, or so I've been told.

I was curious about this myself so I looked up a bit more about this. Here's what I found;

>Even though there have been many publications and patents on the subject, no mechanism has yet been shown to be compelling enough to treat diabetes.[1]

>An apparent more effective strategy is to give insulin glucose-responsive properties that let it respond to glucose reversibly. Merck created a system ... because of its incredibly low efficacy, this system did not merit advancement past phase I clinical trials.[1]

It sounds like they're saying basically that they exist, but aren't yet effective enough to replace the old standard. This particular design is newer.

From the study linked in the article as citation 1: >Here we report the design and properties of NNC2215, an insulin conjugate with bioactivity that is reversibly responsive to a glucose range relevant for diabetes, as demonstrated in vitro and in vivo. NNC2215 was engineered by conjugating a glucose-binding macrocycle and a glucoside to insulin, thereby introducing a switch that can open and close in response to glucose and thereby equilibrate insulin between active and less-active conformations.

Essentially it's a new attempt at making a GRI that's more promising. It's insulin attached to a molecule that binds to insulin to block it from working unless glucose is present, in which case it binds to glucose instead and allows the insulin to be active. Of course that also means it will need to go through full FDA approval process which would keep it about ten years away if it does really end up being effective enough.

But this time could be different! It's very cool conceptually too. The fact that it's possible to make a drug that works like that. It's amazing to see these novel drug delivery concepts develop in real time.

[1] https://www.insideprecisionmedicine.com/topics/translational...

Incredibly shocking how quickly Americans adapted to their government enabling the systematic deaths of thousands. Surely this will leave a lasting impact on those of us who cannot ignore it

Good context.

Right. Take Asianometry-- a channel dedicated to economics, politics, and tech in Asia. Very high quality stuff. He goes into deep detail about a lot of technical stuff.. and as you can imagine his delivery isn't anything like a showman. He can be monotonous but if anything that is likely preferred by his audience, given his niche.

There are some hops based drinks that I enjoy, hop water is the most popular one. They have a few different kinds, some are very strong with the hoppy flavor and some less. They have different varieties with different flavor profiles. I like their main one, hop wtr, though because it has some adaptogens that together with the hops is very relaxing.

Saying "raise your son to be patriotic and fight for his country" is acceptable in western societies. There isn't particularly a big difference in morality when it comes to the extremes

The a/c in my apartment in Chicago is broken. It's a custom size so it's taking a while to fix. The heat is bearable, but challenging. I can see how much more efficient they make things. Just falling asleep takes much longer now. When it gets too hot it can get distracting, it makes it hard to think. I don't want to get up and walk around, I plant myself in front of a fan. I think the level of heat adaptation the human body is capable is limited. You can bear it but it'll affect performance. Even when I maintain a sauna habit, I never adapt to the point that I'm unbothered by the heat. As much energy as cooling homes consumes, it's pretty damn worth it considering you gain comfort and performance benefits

That would be a much less common occurrence. It might make sense to take it "medicinally" as needed, but most people probably aren't getting cut that often. For the general population the risk of heart attack and stroke are probably more relevant

Well you wouldn't necessarily expect to see lowered lifespans, as much as increased heart attacks and strokes(both caused by blood clots). Maybe lifespan would be lowered as an average, but that might be hard to separate from other trends

This is true of opium. They used to give it to babies. This was because they didn't have safer drugs like we do today

It's so hard to get painkillers nowadays that people with chronic pain can't acquire them. The govt listened to this kind of argument and decided to just make everything regulated rather than making everything legal. Not a big surprise honestly

There's also the worry that it will be abused. Kids who want their inheritance, people who have been abused and told it's the right thing for them when it's not, or just insurance trying to save money by avoiding more expensive treatments

Cleaning the brain is one function that is fulfilled during sleep, but it isn't the only function. Even if you can artificially induce this you would probably need to sleep for other things such as physical recovery(which intensifies during sleep). There may be a chance that it helps lessen the need for sleep or maybe even remove some of the deleterious effects of sleep deprivation

They prayed to God that they could adapt to nature. Today people have no faith to turn to, and the system they are in is an artifical maze meant to keep them distracted. There's no hope in the modern scenario.

I don't know if this will work for you, but I've found exercise and using the sauna give me a nice temporary boost in EQ. This makes a big difference for me, enough that it's my go to strategy

I remember there was an episode where this happens with a prison tattoo-- some of them can contain heavy metals that react in an MRI.

I'm a male on the conservative side and think this should all be banned-- most female Americans would disagree and call me puritanical for this. It's seen as part of the culture, a necessary sacrifice for freedom. Blaming only men doesn't help when there are women normalizing this stuff too.

This is an interesting idea, one I'd like to see where it goes

This seems more in line with what I've traditionally seen emulator makers do. Extreme care to insist the program is for homebrew only, with little to no guidance on obtaining ROMs. This legal grey area has existed for a long time. I can see why Nintendo would get annoyed by people trying to profit off of this.

Americans spend a lot of time complaining about artificial Chinese filtering. It makes sense they'd serve them different content.

The community notes? It works surprisingly well over all, although it does get gamed sometimes. Notably, one criticism is that Elon himself gets a lot of community note suggestions but they don't post.

Expecting a publicly traded company not to openly support a military committing war crimes isn't pretentious or shocking, actually. It's quite the norm.

Israel committed war crimes. That's why their researchers are being protested. Everything you said is besides that point.

That could be multiple things. Fasting in general will improve mood. I noticed the same thing and began intermittent fasting. Felt great until I ate. Then I learned part of the reason was because I was switching into keto mode while fasting, which also improves mood. So then I switched to the keto diet to try and capture that feeling full time and not just when I'm fasting. In general I feel a lot better. But even though I do keto and intermittent, eating very little processed foods, I still feel best while fasting. There's a lot going on but I think everyone should experiment with fasting. It isn't for everyone definitely, but some people naturally feel better managing their food intake in that way.

If anyone else did it they'd be reporting it like it's the end of the world

It isn't designed to know things. It doesn't know what exactly it knows, where it could check before answering. It generates an output, which isn't even the same thing every time. So this again is a problem of not understanding how it functions

This article might have made more sense a few decades ago. They're no longer considered as expected as they once were

Aging doesn't seem to be inevitable: some animal species live for very long times even hundreds of years. And yet we have a predetermined lifespan far below that. Seems as though that's an purposeful systematic difference etween species that control how long each generation survive before death.