tomohelix

Scraping by. Doing barely enough to not get fired.

Many reasons. One of them being doctors won't prescribe an off brand drug and insurance won't cover anything related to it.

The other reasons are:

1/ Even the manufacturer doesn't know everything about how the drug was made. They characterize the final compound but the compound was made by some sort of living cells so each one has different properties. For the same molecule, one cell line may produce a drug with entirely different toxicology profile compared to another. You need a full manufacturing chain with different departments analyzing it at different stages to guarantee the desired effect.

2/ Patents make sure that the vanishingly few groups with the capability to do the above characterization would not want to risk their business doing it.

3/ For every one molecule that made it to market, dozens or hundreds of others were discarded. They all cost about the same amount to develop up to the point they were thrown away. Due to the amount of regulations in place, the cost to research is obscene and the final manufacturing cost is peanut compared to the price of the pipeline what the drug went through.

The road to hell is paved with good intentions.

When someone commits an evil act, they did it because they think it is justified somehow. Most bad people do not see themselves as bad at the moment of the act, only as someone who had a reason to do it and the reason was much more important.

The money is irrelevant. An example to deter future attempts is what this is. They are crucifying this guy in the most cruel manner they could and spread the news as much as they can for a reason.

Large (capable) law firms would not want to associate themselves with the underdog in this case. Either because they want to avoid conflict of interest, or confidentiality matters as they likely already have an ongoing relationship with the company initiating the lawsuit. Or simply that the bigger guy paid them to "counsel" and now they have to recuse themselves due to this "relationship".

The smaller guy also likely isn't rich enough to pay for a major law firm either. The game is stacked completely against the individuals going solo against the megacorps. There is no way to win.

This is some dystopian cyberpunk shit people a few decades ago would read in a fiction and think "scary but would not happen for real"...

And the fact is, we all know what this means, what would likely to happen next, and that we are all powerless to stop it. No wonder the younger generations are severely depressed.

I guess it depends on how you measure "power". By "influence and control lives" metrics, Bezos is more powerful than most medieval kings. Back then, a population of 1-2 millions is quite good for a country with the top ones being around 10-20 millions.

Amazon alone directly employs and provide the livelihood for 1.5millions people. That is comparable to a quite a great king in the Middle Age. Amazon also can influence trade and businesses of countless other merchants and groups in other countries unrelated to these 1.5millions employees by means of blocking access to AWS or removing their products from Amazon. Its reach is global, a feat not many kings and emperors of the past could boast.

Assuming it works the way you are describing, that rapid change is what we need right now. People are claiming this year isn't much hotter than last year and drag their feet. But it is much hotter than a decade ago for sure. If we go from 80F summers to 100F then people can't deny the problem. But if we go from 95F to 100F, some guys will say just crank up that AC and don't be a wuss or something.

I wonder if this article is ragebait but I do feel kinda irked when I read things like this.

Coming from a place where the price you see is the price you pay (i.e. most of the world), the US surprised me with the taxes on checkout, then the business's fees, then the waiter tips, then the fucking "valet" who block off the parking lot and gave me no option but to use their "valet" service. By the time I finish paying everything, it could cost double or more what I was seeing on the menu.

I am surprised these things are treated as normal.

I mean, a bunch of rocks falling on a keyboard can also generate tokens. So can an autocomplete software running on a 10W phone. But the quality is so far apart to the point you would find most people do not consider them on the same categories of "inference" as an LLM, not to mention a real human's mental capacity.

A little thing I realize upon reading about all the brain study is how bad we are at reverse engineering a totally alien "computer".

In popular media, human is often depicted as some super scavenger that can exploit and adapt alien technology to their own in a matter of 1-2 lifetimes. And yet here we are in reality, after thousands of years with abundant and intimate access to one of the most efficient and most capable information processor known to us, and we are still absolutely clueless about how it work.

The closest thing we built to mimic it cost maybe a million times more energy and perform a fraction of the functions of the original one. So much for "reverse engineering".

Not really, the answer you are referring to is for completely stopping the moon by delivering enough energy to cancel out its current kinetic energy, of the entire moon!

We don't need to stop the moon to change its orbit. With careful and deliberate adjustments via bombing and letting Earth gravity do its job, we could alter its orbit by adding to its force vector instead of trying to negate it.

For the dollar to collapse in this lifetime to the point you can benefit that way, it will take a major event that would also likely decimate the US real estate market.

Maybe for your children's lifetime, if they are lucky. It took Britain nearly 100 years to deflate from its hegemon status. Argubly, with the size and natural advantages the US hold, it will take even longer for them to naturally fall from its top spot.

It is an ad. New account, waste of space. HN is really getting too mainstream for its own good...

Honestly? Pretty smart move by them. Japan's major export is its culture. Nowadays almost everyone enjoy manga and anime and by extension, they adore Japan. That kind of soft power can be very useful. By allowing unlimited access to their cultural outputs, including copyrighted materials, they can influence the AI and further boost their reach.

You can sort of see this in Stable Diffusion and music models like Suno. Lots of creations are basically Japanese art.

Sora is a thing. It literally walloped everything else in the field to the point the second closest video generation model looked like a broken nonfunctional mess compared to it.

GPT5 might not be the thing we are all assuming it would be. It might not just be a chatbot but an actual AI that can "see" and "talk". By that point, I don't care if performance wise it isn't a big improvement over GPT4 (though it should as we know these models improve significantly when trained with another modal of data, e.g. text+image was much better than text only)

God, I remember a month or two ago when Google released its first music synthesizer that was making distorted songs with barely recognizable lyrics. yet it was a song nonetheless. I was so excited and told myself this thing would probably be much better in a year or two.

A month or two later and Suno is all that I was imagining and even more. The AI tech is advancing like crazy. This right here is an undisputable proof of the value and usage of genAI that nobody can deny. Suno wrote and performed in 3 minutes a song better in almost every categories than those "created" by the likes of Travis Scott or Justin Bieber, at least in my opinion.

Even if the tech is frozen tomorrow and nothing but minor improvements is made, this alone can already shake up the entertainment industry.

Why a pin? Make it a headband or a circlet. Go all in on the scifi-fantasy aspects.

A circlet can be secure in place, has more space for power and computation, and most importantly, fashionably acceptable if done and promoted properly. Not to mention all other benefits such as turning around at the same rate as the user moving their head or easy access to the user's senses (eyes, ears) to provide feedback.

I want my circlet of inteligence +2 now.

I know nothing about economics so please enlighten me: with the yen weakening, does it affect inflation in japan? Say 10 years ago I can have 1 nigiri for 100 yen, which was about $1 back then, does that mean I can have 1.5 nigiri now or inflation catches up and turn out I still can only buy 1 nigiri?

Look to me a significant amount of engineering went into making sure the chip can withstand the amount of power it is drawing. Basically a desperate move by Intel to keep their outdated design from being completely smoked by AMD.

Nothing is absolute in biology. Your edge case can happen, but the chance it happens is so low that it might as well be your body naturally created the tumor in the first place.

As someone who handle cells on a daily basis, I can confidently say these things are the most fragile things ever. You look at them wrong and they will be hurt, literally. What's that? Somebody forgot to feed me today? Welp, time to die. Oh wait, you actually fed me a day earlier? Well, dying time I guess. Hmm, you fed me on the right day but the feed was not warmed up? You guess it, straight to the grave.

For them to be frozen, put in a plastic bag, thawed out, left out for an hour, then exposed to your immune system who gonna be overzealous in killing them and asking them to survive and grow into a tumor is like asking is there a chance a cosmic ray gonna flip a bit in my hard drive and completely corrupt all my data.

Anti-discrimination used to stand for something we needed, that is to stop discrimination and ensure people has equal access. But when that is achieved, like all those with power, these DEI folks instead push the goals forward and make up news criteria to make sure they are still relevant. It is all easy enough, anyone speaking up against them get absolutely destroyed socially and professionally.

So they keep pushing until we are here, in a place where the original intents is all but corrupted and the oppressed has become a symbol of oppression. Meanwhile, there are places where these oppressed minority actually need help but helping them is harder and less profitable than sitting in a nice and secure DEI job in CA...

Depend on how you define "progressive". But it does say something about how the world function.

Imo, CA is more interested in appearing to be progressive than actually being progressive, i.e. making laws that treat the symptoms instead of the root cause and as a result ended up making things worse. Prop 13, "anti-discrimination" laws, tough laws against gas cars, etc. Those backfired and instead of repealing and fixing them, they moved on to making more laws to add on an already gigantic clusterfuck.

It is hard to make real progress. It is so much easier to mess up and never admit to it.

I look at this from another perspective. While you interpet "personal freedom" as a good thing, I see it as an indicator of weakness. Alone personal freedom isn't bad. But when used as resistance against the public good and overall progress, it is a sign that it is being misused, either by malice or incompetence, or maybe both.

America won the world wars by being an industrial powerhouse who could get things built in large quantity. I think that is no longer the case. To go further, it indicates a strategic weakness in national defense. Japan's warships were technologically superior to the American's. The German tank' specs were better than the Allies. But they lost on the number games. I feel like if a fight broke out between the US and China right now, we may see the same thing happen again, except this time, the US is the one playing the "few elite" card while China has the industrial and manufacturing power to swarm us with "good enough" war engines. And history has shown twice which strategy would win a war.

Clickbait trash. Here is the entire article: Enable verbatim search.

Which doesn't mean much recently anyway. At least in my experience, Google is still shit no matter which method I tried.

To train AI, you want contents that are human generated. So since Google is interested in the AI race now, filtering out AI contents is high on its list of priority. We are lucky it "trickles down" into us in this form.

Otherwise, Google being Google would ignore this issue just as they have ignored all the SEO and bot spams in the past. They lost their visions and has succumbed fully to corporatitis. I think anything short of a major surgery or blood transfusion would save Google now.

After reading this thing, first thing I did was laugh. Second thing I did was thinking maybe they wanted me to laugh. Third thing I did was laugh at myself for being such a paranoid idiot.

Entertaining article overall.

One of the most beautiful parts of Japan is the mix between the old and the new. Japan maintained not just the physical parts of its root (buildings, objects, etc.) but also the human traditions and culture and social aspects.

It also preserves the bad parts, like xenophobia and racism and work culture. But it what make them unique and fascinating to an outsider.

It means the publisher no longer host/publish the papers. This can be done at the request of the author or by the publisher in the case of a controversy.

In this case, it seems there is no particular issues with the content of the paper, just that the way the data was collected was not appropriate. A case can be made about the narrow set of data (focused on minority groups) and thus how representative the data is to whatever claims made in the paper. But that require a deeper read into the papers themselves and has nothing to do with the main complain, i.e. ethical concerns.

I mean, 1 out of 4 isn't really a good thing, especially when it was so blatently wrong on 2 of the other 3.

To be fair, we don't know what was the previous prompt. Maybe the guy enforced a rule to include as many ethnicity as possible so the AI has to try to put in a bunch of Native Americans and blacks. But if so then where is the Asian? Most "culture war" also often miss out on this huge group of people for some reason...