Sorry about the throwaway account. Would rather not link the numbers to the site at this point. Revenue about $60k/month; fairly even mix of affiliate programs (mostly a couple big ones) and advertising (mostly adsense/ad exchange). Earnings before taxes and my draw ~ $500k/year.
Have tried out many alternate ad networks and exchanges, and the only other one I've found worth taking space from google so far is AOL's new Advertising.com. Individual relationships and niche affiliates can be worthwhile too, but come with more overhead. I'd generally rather optimize UX and try to attract more users than worry about managing a bunch of advertiser relationships. For a larger or smaller site that would probably change though.