Okay link it?
4,473 karma · joined January 1, 2022
I still do not know what your main points are here. This study isn't going to be replicated yet because it is considered a "breakthrough" and only two months published. It is going to have limitations because all studies do and authors disclose what they think are their limitations.
Also I haven't downvoted anything for what it is worth.
There is also a great re-cap of this work here:
I have read thousands of covid / long covid papers. I think you would be surprised at what symptoms persistent virus in the gut lead to:
https://www.cell.com/cell/fulltext/S0092-8674(23)01034-6
The books "I contain multitudes" and "Gut" are excellent recent titles helping bring light to the power of the gut. I personally think some other organs may be involved too and even the vagus nerve. But none-the-less covid is hijacking mitochondria:
By Vannevar Bush
https://medicalcountermeasures.gov/nextgen/
Goes to show that if you align incentives, remarkable things can happen.
Accounts need to verify themselves somehow.
Accounts should be old enough before contributing reviews.
Accounts should only be able to review X amount of titles an hour/day/etc.
Moderators should have tools to identify influx of reviews and decide mitigation strategies.
Moderators should be able to put up a banner on a title that may be review bombed so the community can report suspicious reviews.
Etc.
These aren't honestly policing much. Just general common sense for these platforms. Also heavily needed on many other platforms that get spam in similar ways.
> Everything should be made as simple as possible, but not simpler.
Isn't it clear that scale governs the self-determination theory? You can run a company much like a startup if you choose to. Many people/businesses do not choose to do that and that allows bureaucracy and hierarchy to thrive.
This isn't a "product manager" problem. This is a loss of identity or culture. Many of your great people will leave because of this eroding. Blaming it on product managers is lazy because it shows you aren't looking close enough.
I personally cannot stand the former where publishing teams will buy or fake mass amounts of reviews to play into the NYT bestseller formulae.
It is fairly easy to tell an ad hominem in a "review bomb" in my experience. Usually it relates around politics or something controversial rather than the actual thing itself.
The science is not perfect. Vaccines aren’t sterilizing, current treatments aren’t effective enough to prevent disease progression, and we are only approaching the 5 year mortality mark.
When we develop more effective vaccines and treatments, perhaps we will see this start to settle alongside all the other challenges that continue to get worse.
Alan Watts has a number of talks on Wu Wei and visualizations.
https://www.youtube.com/watch?v=eeD3wS4fGEY
Additionally the metaphor through "The Tao of Pooh" does a great job as well.
https://wikipedia.org/wiki/The_Tao_of_Pooh
They might be Western bastardizations of what it really means, but they inspired me to write a take on it:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770761/
I hope that if we find a reversible cure through antivirals, gut modulation, monoclonal antibodies, etc, that Mr. Chia gets the recognition he deserves given his influence on these hypotheses.
https://www.sciencedirect.com/science/article/pii/S073567572...
https://www.thelancet.com/journals/laninf/article/PIIS1473-3...
No. long covid "Brain fog" is clearly caused by the SARS-CoV-2 pathogen. Acquired ADHD has a much broader umbrella of brain injury, infections, environmental factors, and medical history.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3... suggests that various symptoms included in the definition of long covid "brain fog" can be improved by balancing the gut microbiome. The gut is where we produce 90% of serotonin.
So another way to think of this might be "could long covid lead to conditions common of gut dysbiosis?" your answer is what we are seeing in research:
- Depression.
- Anxiety.
- Alzheimer's disease.
- Attention-deficit/hyperactivity disorder.
- Autism.
- Bipolar disorder.
- Dementia.
- Obsessive-compulsive disorder.
- Post-traumatic stress disorder.
- Schizophrenia.
- etc
Jeeze some of these are crazy. The notable one I was aware of was Paxlovid.
https://www.ncbi.nlm.nih.gov/research/coronavirus/
I'm not arguing for or against preventative measures. I am arguing that our health officials could do a better job discussing what we know about it now to help individuals make choices.
You also have countries like Germany who are starting to realize the actual burden of infecting the general population and necessity to follow what current evidence we have to tackle the long-tail issues:
I think what people are more interested in is whether people who are dutiful with covid pre-cautions actually work(kids are a tough cohort). I think we know the answer there too.
For example, a systematic review of professionals in a workplace with mask policies versus those without.
Or systematic reviews on other helpful topics like ventilation, filtration, and testing from different cohort perspectives like kids and adults.
The current consensus we all have today is just "don't get infected" which does humanity very little good. There are evidence-based approaches that need to inform public policy makers and for those policy makers to be very clear with the public on what the risk each person entails without pre-cautions.
The right question as alluded to in this article being "where are you happiest working?" is equally dumb. Of course people are happier in their preferred environment.
This whole discussion is just a distraction and the points don't even matter as to who wins the argument.