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Comment by thenerdhead | Hacker News Reader

My RHR baseline(average) is 51. HRV baseline(average) is 95. I sleep very well & consistently but wake up feeling wired & tired (common in chronic fatigue I suppose). My cardio fitness averages to 52.9 which is a measurement of my VO2 max.

I have read thousands of covid / long covid papers. I think you would be surprised at what symptoms persistent virus in the gut lead to:

https://www.cell.com/cell/fulltext/S0092-8674(23)01034-6

The books "I contain multitudes" and "Gut" are excellent recent titles helping bring light to the power of the gut. I personally think some other organs may be involved too and even the vagus nerve. But none-the-less covid is hijacking mitochondria:

https://pubmed.ncbi.nlm.nih.gov/37556555/

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Did you look carefully at that serotonin paper? It's pretty underwhelming. Check out the comments on s4me if you haven't already:

https://www.s4me.info/threads/serotonin-reduction-in-post-ac...

There is a lot of crap science published, and that serotonin paper is pretty poor.

Anyway, it's up to you what science you want to pursue. I managed to recover from ME/CFS myself by looking deeply into the science, so I'd recommend looking further. Stress seems to be one of the major issues. Anyway, from what you say it sounds like your symptoms are pretty mild (correct me if I'm wrong here).

Thanks for sharing your opinion. I don't share it, but appreciate you taking the time.

Okay, you believe you have persistent virus impacting your systemic health, possibly by allowing other opportunistic infection, then you would take an antiviral.

Let us know what happens after that?

Or this:

https://www.medscape.com/viewarticle/monoclonal-antibodies-n...

No, I have no opinions on that serotonin paper. I was just referring to the facts, which are that other papers haven't replicated its findings and there are a lot of factors that affect serotonin that they haven't taken into account. If you're interested, take a look. If not, no worries.

Look, I'm more than willing to hear your opinion but I'm not going to dig for yours in a forum post. I took one look and immediately sent you that comment because those are opinions I do not even remotely share besides the last post of someone who linked a detailed newsletter talking about why this work is important.

There is also a great re-cap of this work here:

https://youtu.be/278vwGkFXRM?t=13406

Fair enough, its always better to analyze it yourself and check the validity of any particular research or criticism of such research. Opinions in science arent really useful unless they are weakly held and based on the evidence. If you have any response to the main points i posted above feel free to post. As i said i have pretty much zero opinions on this, and have only looked at it very briefly.

PS downvoting good faith discussion is bad form.

What are you saying here? That this entire paper and subject area is an "opinion"?

I still do not know what your main points are here. This study isn't going to be replicated yet because it is considered a "breakthrough" and only two months published. It is going to have limitations because all studies do and authors disclose what they think are their limitations.

Also I haven't downvoted anything for what it is worth.

Another study has already been done and failed to replicate this from what I can see.

Okay link it?

It was in the s4me discussion. I think the more interesting question is why you put so much stock in a study you admit is exploratory, which you havent checked for validity.

Two studies that explore metabolic pathways in different ways. That doesn't mean they "failed to replicate". This happens all the time in science, especially EBV research. For example they failed to find EBV reactivation in long covid in one study, but then also found that it is a smoking gun in others. Aside that, what is your gripe with the Penn study?

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