theatraine

Josh Mitteldorf's blog is good for life extension updates: https://joshmitteldorf.scienceblog.com/

Interesting idea. Does anyone do this for Azure?

How often does the CEO change though? What would the alternative strategy be? If you feel that the CEO is likely to get replaced or that the CEO is likely to change strategy isn't that a good signal that you should be looking to work at other companies?

You can modify the algorithm to do n-degree contacts as well though and then you can propagate a positive test through the network accounting for time delays. Contact tracing should allow you to be more effective with fewer tests since you can ensure that people who wouldn't normally self-isolate do so.

It's roughly 9 hours of coding and 3 hours of brainstorming with my co-founder. I do notice that my focus wavers quite a bit. Meditation has helped with this to a certain extent.

Health is my first priority so I make sure I'm getting enough sleep and regular exercise. When I'm feeling particularly stressed I'll go to Banya. This helps prevent burnout.

I've also reduced the time it takes to do most everything. No commute, gym in home, no time for grocery shopping (Amazon Prime Now), no drinking, and I'm single.

I never understand these studies. I'm bootstrapping a startup and my work output scales linearly with hours until about 60 hours per week. 60 hours per week is comfortable with 4x12 hour days and then 12 hours over two shorter days. To accomplish errands and the like I just do things before 2pm which is plenty of time.

For me personally more time working = more output. What am I missing?

I should note that I have no family, no commute, and my gym is in my home so I'm able to save some hours on those things. I could see how in those cases one would have less time for work.

Kombucha is a great vegan source of B12, one of the key nutrients mentioned in the article. The B12 in kombucha actually comes from the culture itself.

I've found that meditation has also helped me. I read several books on the subject of meditation but found "The Mind Illuminated" to be the best.

This study uses an inscrutable statistical model to arrive at this conclusion. On the other hand I have yet to see an epidemiological study that shows abstaining results in a lower hazard ratio than moderate drinking.

Consider the following study: https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736... This study only calculates HRs between current drinkers, finding that the lowest mortality rates occur below 100g/week of alcohol. The issues with the conclusions of this study (issues which are apparent in many other alcohol studies) are addressed in the follow-up here: https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736...

I'm sure that similar issues exist with "Alcohol use and burden for 195 countries and territories" but the statistical model is too complicated to really see what's going on. I agree that at a population level alcohol is bad for longevity but at an individual level there seems to exist no evidence to suggest that moderate drinking is.

I'm 2.5 months sober and this has been my experience as well. I'm now much more wary of getting myself into situations where I might be bored. I'm naturally extraverted so I still enjoy the social aspect of parties but I've cut back on the amount of dates that I go on since the risk of being bored is too high.

I've started meditating to try and raise my "boredom tolerance". It's too early to say if it has made any difference but I've met people who swear by it. I'm also trying to get more curious about other people and essentially rely on my extraversion to deal with boring situations.

In terms of substances to fill the niche I don't think there's anything that exists. Coffee is nice during the day but drinking it past a certain time leads to insomnia. I've mostly just taken to drinking a wide variety of non-alcoholic beverages LaCroix and non-alcoholic beer.

Pharmacologically speaking the closest drugs would be GABA receptor agonists (e.g. phenibut, benzos, GHB) but those can be quite nasty and even more addictive than alcohol. I have not personally tried them and don't plan on it.

I have never understood this and this very issue has caused trouble in my romantic relationships.

Here's my thought process: why would someone talk about something if they don't want input? It seems like a waste of time.

Where's the gap in my thinking? Is there some way I can mentally reframe my thought process so that I 1) Don't immediately try to solve the problem and 2) Don't get annoyed at my significant other for wasting my time.

I didn't see this, thanks for posting it! My thought process was really similar to the author's actually and I've been happy with the results so far. I've distributed the lights around my room with shades to mitigate the unpleasantness factor as opposed to going with the "megabulb".

I absolutely agree. As an aside I also have a CO2 monitor (Awair device) and make sure to keep my bedroom/home office below 700ppm. This is easily achieved by keeping the window open. Self experimentation has shown that I tend to yawn quite a bit more at levels greater than 1000ppm.

Thanks! My only other recommendations of similar books but have already been mentioned would be the Steve Jobs book by Isaacson and Surely You're Joking, Mr. Feynman!

Tangentially related: I've been experimenting with very bright lights from when I wake up to sunset. In my bedroom/home office I have a couple 6000k LED lights at 8100 lumens making the room almost as bright as noon outdoors. Post-sunset I use dim red lights. I was inspired by SAD lights but didn't like any of the ones I tried so went with high-powered "corn" LED lights in normal fixtures.

I've noticed that I tend to get sleepier at night which is great as before I would have to force myself to go to sleep (I'm a natural night person.)

I've also noticed a small increase in my distance visual acuity (subjectively measured by me using an eye chart so not the most accurate.) I have read that intense outdoor light protects against myopia (see https://www.ncbi.nlm.nih.gov/books/NBK470669/) so I suspect this is related.

Some great books have already been mentioned but those which were the most personally influential which haven't yet been mentioned:

- Total Recall: My Unbelievably True Life Story by Arnold Schwarzenegger

- Elon Musk by Ashlee Vance

- Bad Blood by John Carreyrou

- Kochland by Christopher Leonard

- Masters of Doom by David Kushner

I read a lot of "business consultant" books and began to be annoyed with them since many of them can be summed up by the title and the first couple of chapters.

I like the books above because they presented factual events that allow you to draw your own conclusions.

I especially like Schwarzenegger's book and Bad Blood because of their depth. It was interesting to hear about Schwarzenegger's crazy business ideas like how he became a millionaire before becoming an actor and how he bought a 747.

I found the audiobook "Master's of Doom" (book is 2003 but audiobook is newer) to be really entertaining as it was read by actor Wil Wheaton who did a great job.

It's certainly possible that the relationship is not causal and can be explained by correlations with depression, unemployment, sleep apnea, etc. However I'm not aware of any study that definitively proves this. It would be great to see a study similar to what you propose.

In general I'm fascinated how too much of a good thing leads to increased mortality and small amounts of a bad thing leading to increased longevity via hormesis and would love to see if the same extends to sleep.

Some examples of hormetic longevity influencers: caloric restriction, alcohol consumption, exercise. Even DNP a straight up poison has been shown to be increase lifespan in animals provided the dose is small.

There seems to be quite a lot of information about why <7 hours sleep is bad for you, but I'm more interested in why sleep >=8 hours is associated with increased mortality.

See for example https://www.ncbi.nlm.nih.gov/pubmed/29790200 (an interesting study in itself).

I read "Why We Sleep" but unfortunately it didn't answer this question. The association could be correlational but it's been replicated too many times for me to believe that there's not something more fundamental. Perhaps there's a hormetic effect that's blunted by too much sleep similar to how HGH is bad for longevity?

Normally I would be inclined to agree with you but the article specifically says: "The research has some important limitations including ... the subjective measure of sleep being based on time spent in bed rather being asleep per se"

I saw this with a partner. She was extremely agreeable and would compromise her own sleep to make time for others. I suppose that doing this over time adds up and extracts a toll.

Thanks! I pull conventional, I'm no good at sumo.

I would agree that multi-day fasts would not be good for strength sports. There doesn't seem to be a authoritative source but LeanGains states you won't lose muscle if you're fasting less than 24 hours. (https://leangains.com/top-ten-fasting-myths-debunked-major-u...)

Personally I haven't noticed any reduction in strength doing 8 hour time restricted eating. I've hit my most recent PRs doing this. For reference I'm decently strong with squat/bench/deadlift being 470/320/545 lbs.

What country and tech? I haven't heard of this before and I wonder if it's a recent phenomenon due to the strength of the US dollar.

I've been experimenting with mouth taping recently. When I'm able to use it effectively it does result in a much more restful sleep and my blood pressure seems to be lower the next day. I believe that the lowered blood pressure is due to the enhanced nitric oxide absorbed (it's produced in the sinuses). Unfortunately I'm frequently congested so it's difficult to do this without the use of a decongestant.

I'm reading Aubrey de Grey's book Ending Aging right now. I'm finding it to be a good read and a great introduction to his approach, SENS (http://www.sens.org).

Author here: I run another site and I noticed that session recording tools, although super useful suffer from an information overload issue. When I tried to use other tools such as HotJar or FullStory I could only look at a small amount of examples before I was overwhelmed by sessions.

That's what inspired my team and I to build Asgard, but I wanted to share some simple techniques that could be applied to existing FullStory data.

Time restricted eating is probably the most compatible with weight lifting.

Personally I'm interested in longer fasts but I'm under my goal weight. I would also be interested in more research about how to gain muscle while fasting.

Are there products that are already using probabilistic inference for debugging already? How mature is this approach?

It's hard to say if it would have helped. My rationale would be that the engineers commonly dogfood their own products and do ad-hoc testing so a black engineer may have been able to catch the bug before it hits production.

Taking the example to the logical extreme I doubt the bug would have hit production if the entire development team was dark-skinned.

I'm curious if anyone has examples where diversity led to better product creation, or counterexamples where companies were hurt by since the designers overlooked certain groups. One notable example was Google photos racist blunder: https://www.bbc.com/news/technology-33347866

Arguably Apple not focusing on women's health for the longest time could have also been mitigated by more female product people as well.