Ketamine treats symptoms and is more like a bandaid from what I see, and comes with its own problems (addiction). Psilocybin and ayahuasca when used properly can help you to process and resolve many types of problems (traumas, past drug/alcohol use, sins). But you have to be willing to work (if you can't bear it alone, this is where the curandero or therapist comes in. If that idea doesn't work for you then probably stick to ketamine)