189 karma · joined March 13, 2018
Haven't read your link yet but I'd expect a double vaccinated 65 year old is still waaaaay more vulnerable than an unvaccinated 18 year old.
I expect what could see is stubbornly elevated hospitalization and deaths in the high risk groups :( Bad for them but also bad because the way that politicians trying to drive health policy under mistaken assumptions will react.
Let that sink in for a moment...
The best way to boost overall vaccine effectiveness is to extend it lower risk groups - healthy children and young people - regardless of whether they really need it or not.
'The rapid waning of antibodies did not necessarily have implications for the efficacy of vaccine candidates currently in clinical trials, Imperial’s [Wendy] Barclay said.'
“A good vaccine may well be better than natural immunity,” she said.
https://www.reuters.com/article/uk-health-coronavirus-britai...
https://www.google.com/search?q=“A+good+vaccine+may+well+be+...
'Latin America’s embrace of an unproven COVID treatment is hindering drug trials'
https://www.nature.com/articles/d41586-020-02958-2
Hopefully it would be noted in the limitations section of the trial paper, but the writers of media articles are often polarized or biased and just cherry pick.
ETA, personally I would prefer small well designed trials from researchers with historical expertise who provide plenty of accompanying information and are willing to discuss the results, eg Chaccour et al:
'The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial'
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5...
https://www.youtube.com/watch?v=yIUO08W94eY https://www.youtube.com/watch?v=JuzHG0rpOrc
He also said:
'I've unkilled it so you can respond now. It's not really on topic for HN though. Too much of a provocative opinion piece and not enough significant new information (https://hn.algolia.com/?dateRange=all&page=0&prefix=false&so...). That guarantees a flamewar, which we're trying to avoid on HN.'
I thought it was worth posting because it was written back in August 2020, so was quite prescient.
IMO a number of high profile politicians and corporate media are also guilty of misinformation.
Eg 'pandemic of the unvaccinated'. This seems to equate no immunity with naturally acquired immunity, and must surely be misinformation, but much of the media is blind to it.
https://youtu.be/73KWHPsw-ag?t=525
He states that '4% seropositive having symptoms after 12 weeks', but omits to mention that 2% of seronegative have symptoms after 12 weeks too...
Also he doesn't mention the 9%/10% rate split at 4 weeks, or the symptoms:
Tiredness, Headache, Congested or runny nose, Stomachach, Sleep disturbances, Cough
So he's making the case for child vaccination on the basis of 2 extra seropositive children having one or more of the above symptoms.
And, BTW, the study authors themselves note the limitations as follows:
'Limitations include the relatively small number of seropositive children, possible misclassification of some false seropositive children, potential recall bias, parental report of child’s symptoms, and lack of information on symptom severity.'
The study authors concluded that:
'Seropositive children, all with a history of pauci-symptomatic SARS-CoV-2 infection, did not report long COVID more frequently than seronegative children. This study suggests a very low prevalence of long COVID in a randomly selected population-based cohort of children followed over 6 months after serological testing.'
According to the UK govt's own figures, the 28 day case fatility rate is 2.0% for the Alpha variant, and 0.3% for the Delta variant.
See page 8:
https://assets.publishing.service.gov.uk/government/uploads/...
OK it may be that hospital treatment and vaccination (of the vulnerable) have greatly improved the CFR, but as of now mortality risk of the Delta variant is rather more modest compared to some earlier variants.
Polarization is the mRNA of disinformation.
The brokenness usually comes from a diet high in overly processed food and refined sugar/starch, often coupled with little or no exercise.
Here's a paper relevant to the diet aspect:
Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake:
https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248...
I believe a good way to un-break things is gaining an awareness of where the calories are coming from, together with a. lot. of moderate exercise.
The above has worked well for me, but it's no quick fix, and wouldn't sell books, tv programmes, or speaking engagements.
'Eat less, move more' is overly simplistic, it's more about how you eat less and how you move more, to help the body's set point to shift back to a healthy level.
https://news.ycombinator.com/item?id=25735404
'The history of a pioneering tube that was developed by Philips Research and that was, next to the magnetron, “The most important tube from World War II” - Ronald Dekker'
One of the problems Bowen was facing was that while early 1939 all components of the Airborn Radar seemed to have fallen in place, he still had only one receiver which up to that moment no supplier had been able to duplicate. But then quite unexpected his old professor comes up with a golden tip:
"Quite by chance in april or May of 1939, I heard some encouraging news from Edward Appleton, my old professor at King’s Colledge and now Jacksonian Professor of Physics at Cambridge. He told me that the Pye Radio Compagny, still hoping that there would be a television industry in Britain, had set up a production line for 45 Mc/s TRF chassis and had actually made a trial run. I went hot-foot to Cambridge to see B.J. Edwards, the Technical Director of Pye Radio, and was rewarded with a remarkable sight – he had scores [!] of TRF chassis just the type we were looking for. These used a new valve with an octal [sic] base, which had not yet appeared on the market. It was the EF50, a valve which was destined to play almost as important a part in Radar war as the magnetron itself."
Bowen took a few samples of the Pye chassis back to Bawdsey and quickly verified that it was significantly better than their old EMI chassis; it was also smaller and lighter. Touch and his men quickly put a 200 MHz mixer (at that time still based on an acorn tube, but later replaced by an EF54) in front of it and the receive problem was as good as solved.
(Only works if the dev/debug code is added in some sort of properly planned and documented way I guess.)
This is what the aborigines in Australia used to do:
'To Help Australia, Look to Aboriginal Fire Management'
https://www.yesmagazine.org/environment/2020/01/13/australia...
https://www.youtube.com/watch?v=-wtGFgaKYI0
EDIT: One highlight is where Alan Cooper gets a cease-and-desist letter from Microsoft for calling himself 'The Father of Visual Basic'...
A poor connection at a plug can (or will?) cause a hot spot without arcing, and for a long thin cable a short may not even trigger the overcurrent protection of a high power charger.
Best to buy a cable with a decent 'AWG rating' eg 24AWG, either from a reputable brand like Tronsmart, or a specialist supplier, in the UK there's Kenable:
Initially in Feb he was all about vaccines [1], then in a revealing interview on the Ellen show in mid April he mentions them in passing [2], next in late April he suggests a role for them in easing the lockdown [3], and finally in June (in a somewhat revisionist interview) he castigates the american public for not wanting to wear them [4]
[1] https://www.gatesnotes.com/Health/How-to-respond-to-COVID-19
[2] https://www.youtube.com/watch?v=5oEcxMfwJnw
[3] https://edition.cnn.com/2020/04/26/business/bill-gates-coron...
[4] https://www.fastcompany.com/90520896/how-do-we-beat-coronavi...
Contrast this with a number of medical experts in Asia whose simple advice back in January basically nailed it, including the need for mask wearing, eg:
https://www.youtube.com/watch?v=dcbJdRb6mds
It's a cautionary tale that even the richest philanthropists with the best advisers can fall considerably short, and may not even be aware of it...