I just got back from 6 months traveling Europe and working. I traveled with my Wife and two small children. No regrets and now that we are back (for a while), I'm ready to do it all over again. No matter how many photos of friends/acquaintances who have done it and their always smiling photos - its still real life. Not every day is rainbows and butterflys.
Routine (as others have stated) in very important to define. If you are traveling with others, it needs to be expressed as soon as possible and if at all possible, define the items which might allow you the chance to break it. When traveling, so so so many opportunities will come up that will test your resolve to sticking to the routine.
Try staying places for longer stints. We averaged about 3 weeks at each place we stayed. This allowed us to stretch out the activities over time and not feel guilty about sticking to the routine or letting the kids just chill. It doesn't have to be 'go go go' all the time.
If you know where you are going to stay, spend some time figuring out where you are going to work before you get there. For me, it was hard to work at our flat/apt/house because the kids knew I was there and wanted to hang out with me because it was great having me around - compared to before we left having the normal 9-6 work schedule. It isn't always easy finding a place that has good internet, seating, and won't kick you out for hanging out all day on a couple cups of coffee. Coworking places are in most major cities, but hours can be limiting and they aren't always around the corner.