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slumdev

701 karma · joined February 27, 2019

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slumdev··on FDA Approves First Covid-19 Vaccine
It's actually the math that I'm questioning, not the subjective aspects.

The quantity of money required to support my family in the event of my death is not affected by the odds of my death.

Whether I'm the perfect image of health or an obese, chainsmoking, binge drinker, the mortgage bill is always the same amount.

slumdev··on FDA Approves First Covid-19 Vaccine
> the NVICP is perfectly sufficient for my own needs

How do you reach this conclusion?

At a max $250k per life, paid through a secret court with the deck stacked against the plaintiff, it doesn't appear to be sufficient for anyone's needs.

slumdev··on FDA Approves First Covid-19 Vaccine
> Well, what would it take for you to change your mind?

A vaccine that (1) did not use cell lines from aborted fetuses at any point in its discovery, development, testing, or production, and that (2) has been studied for 10 years to determine long-term safety and efficacy like we would do with any other vaccine.

What would it take to change your mind?

slumdev··on The mutation that helps Delta spread
See my reply to a sibling comment. The most damning evidence comes from the comparison between highly-vaccinated Israel, where there are many third-wave deaths, and mostly-unvaccinated Palestine, where there isn't a third-wave death spike at all. Having mostly-unvaccinated Palestine as a control group is showing us that we don't know what we thought we knew.
slumdev··on The mutation that helps Delta spread
A study demonstrating the mechanism for Delta ADE in vivo: https://pubmed.ncbi.nlm.nih.gov/34384810/

Highly-vaccinated Israel's third-wave surge in both cases and deaths: https://www.worldometers.info/coronavirus/country/israel/

Unvaccinated Palestine's lack of third wave deaths: https://www.worldometers.info/coronavirus/country/state-of-p...

slumdev··on The mutation that helps Delta spread
SARS-CoV-2 has four antigens. The existing vaccines stimulate the production of antibodies against only one of them, the spike protein.

The existing vaccines are proving ineffective against Delta because it has mutated significantly enough that its spike protein does not cause a neutralizing immune response. They may even be causing ADE, as evidenced by the most recent data comparing Israel and Palestine.

slumdev··on Launch HN: Ancana (YC S21) – Fractional ownership of vacation homes
If you ever relinquish majority ownership of this company in exchange for funding, it will eventually become "Timeshares But As An App".

Your approach might be more principled than the way timeshare companies operate. But it also sounds like you're leaving a lot of money on the table, compared to the way timeshare companies operate. And investors won't let that continue if you can't convince them that your approach will somehow make more money than timeshare companies.

slumdev··on Launch HN: Ancana (YC S21) – Fractional ownership of vacation homes
Who becomes owner of a person's share if he stops paying maintenance fees?
slumdev··on Fructose in diet expands the surface of the gut and promotes nutrient absorption
It's even more complicated than that. Some nutrients are absorbed in the stomach. Most are absorbed in the small intestine. Some are absorbed in the large intestine.

Heck, some are even absorbed through the mouth and gums!

slumdev··on Don't Call Yourself A Programmer, And Other Career Advice (2011)
> Yeah, WTF is wrong with that

Nothing is wrong with it. Donald Knuth proudly describes himself as a programmer.

But a good chunk of the people reading this comment probably make more money than he does, and title inflation is part of the stupid game we have to play to earn outsized rewards.

So proceed with caution.

slumdev··on Don't Call Yourself A Programmer, And Other Career Advice (2011)
The people who can't code any longer are still typically able to describe an algorithm, at least in pseudocode.

Whiteboarding Yet Another Graph Search Problem With Perfect Syntax[1] might be beyond their current short-term abilities, but I'd be surprised if they couldn't produce pseudocode and architectural design that solves most real-world problems.

On the other hand, there are plenty of "seniors" who couldn't write code in the first place.

[1]Everyone knows which employer does this.

slumdev··on Hire for slope, not Y-Intercept
Yep. I think we run into a different problem, which is the diminishing return to the employer.

Even if a person's growth is linear, most companies' ability to realize a return on that growth probably isn't.

It's not that the companies couldn't benefit from experience if they knew how to realize that benefit. It's more that their processes are set up in a way that prevents the benefit from being realized. I'm thinking about heavy-handed architectural diktats and constantly changing priorities when I write this.

slumdev··on Hire for slope, not Y-Intercept
A lifelong learner with decades of experience will outperform a 5-year "senior" many times over, not just in output but also in the headaches and mess that they save you from having to experience.

What we need is better titling. There's nothing shameful about being a junior or a mid-level for multiple years each. Until we get that, one can usually tease out the "seniorness" of the position by discussing salary.

slumdev··on Moderna Is About to Begin Trials for HIV Vaccine
> in several countries the bulk of transmissions are from mother to infant during delivery

Is this the case in the United States, where the CDC makes recommendations?

And if so, why not administer it only to those children of mothers who test positive?

We don't put everyone on a statin simply because most (i.e. more than half of) people will eventually develop heart disease. Instead, we test and administer statins to only those people who have heart disease risk factors.

We don't give everyone bariatric surgery or weight loss drugs simply because most Americans are overweight or obese. Instead, these remedies are administered only to those who are most likely to benefit.

No drug or vaccine is without side effects. It's clear that there's no such thing as informed consent in today's world. The patient cannot be informed because the side effects are hidden from him. And he definitely hasn't consented if coercion was involved in his decision to receive the treatment.

slumdev··on Moderna Is About to Begin Trials for HIV Vaccine
Pray that the side effects are well-studied before the CDC decides to administer it to every infant within minutes of birth (like they did with Hep B, another sexually-transmitted disease to which most people will never even be exposed.)
slumdev··on Aspartame and cancer – new evidence for causation
Artificial sweeteners, from the time that they enter your mouth and encounter your taste buds, cause the release of insulin.

This insulin lowers your blood sugar. Because artificial sweeteners provide only the sensation of sweetness and not the energy content of an actual sugar, your blood sugar falls low enough that your unconscious brain is compelled to eat.

People who drink diet soda consistently eat more calories than they would have eaten if they had drunk a regular soda--even if you include the calories from the soda.

slumdev··on Aspartame and cancer – new evidence for causation
No matter what they say, nobody likes fruit enough to get fat off of it.

Can't say that about candy bars.

slumdev··on More than 75% of Job Posts are Remote
> Was paying under $700 for the two of us.

What did this buy, though? That premium sounds like either a "health sharing ministry" or some kind of barebones catastrophic plan. Both are smart options if a person has good income and a financial cushion, but they're a much lesser coverage than what most big employers would provide.

> if 1099 is ~25% more than W-2, odds are pretty good you can do better on your own

I've used a wider margin as a rule of thumb when considering it in the past. I'll have to rerun numbers based on my current income and benefits.

> especially if you take advantage of the solo 401(k) to reduce your tax load.

That secret $54k deduction... probably the biggest benefit for anyone who is moderately high-income and retirement-minded.

slumdev··on More than 75% of Job Posts are Remote
> when I was working as a 1099 contract worker, I bought health insurance for my family for little more than what an employer deducts from my paycheck.

How long has it been since then?

What most people would consider "good" insurance costs $1500-2000 per month for a family.

I've never seen an employer chip in less than 50% of that cost.

slumdev··on Am I stuck in a local maximum?
Most ORMs don't let us do this, and it works well.

Getting back the entire relation (rather than some sub-tuple) isn't the kind of expense that causes problems scaling. It chews up network bandwidth between the database and the API, but it's not more computationally expensive (asymptotically).

And if my entities are dozens of columns wide, I'm probably not in 3NF anyway, so it'd be better to focus my efforts on getting there.

slumdev··on An old hacker's tips on staying employed
This is real diversity--some single, some married, some with kids, some without, some older, some younger, coming from all different educational backgrounds, and living in different communities.

If everybody went to the same handful of colleges, is roughly the same age, and lives in the same trendy suburb, it doesn't matter what color they are. That "diversity" is literally skin-deep.

slumdev··on Am I stuck in a local maximum?
It's a feature, not a bug, that the code blows up when the database schema doesn't match my models.

Just as the necessity of DI frameworks isn't an argument against unit testing or the inversion principle, the necessity of ORM frameworks isn't an argument against static typing or relational databases.

slumdev··on Facebook announces privacy-enhancing technologies
"OPEC Pivots To Renewable Energies"
slumdev··on Am I stuck in a local maximum?
This is how most non-tech Fortune 1000 companies run.
slumdev··on Am I stuck in a local maximum?
> I have arrived at the same conclusions as you wrt. static vs dynamic typing. A sufficiently powerful static type system entirely subsumes dynamic typing, and there is quite literally nothing you can accomplish with dynamic typing that you cannot accomplish with such a static type system. After writing software using both dynamically and statically typed languages, this is the conclusion I have arrived at, and it feels like a no-brainer to me.

I've come to the same conclusion. A dynamic language is a footgun that doesn't buy any additional power or expressiveness over a well-developed typed language.

It gets even worse when dynamic language developers start interacting with data. The "just do whatever" mentality that rejects type design also rejects relational design without any consideration of whether it's (almost certainly) a better choice than a document database.

slumdev··on The 'Great Resignation' is really the 'Great Discontent'
I bet they wish they had leased! This employer owns many large campuses...
slumdev··on U.S. Kids Are Getting Nearly 70% of Their Calories from 'Ultra-Processed' Foods
And yet:

- Cold-pressed, extra virgin olive oil is considered to be the healthiest due to its fat and polyphenol content.

- Traditional cheeses are more nutritious than Kraft singles.

- Whole grain is more nutritious than Wonderbread.

- Freezing, cooking, and the passage of time all destroy vitamins and other micronutrients.

slumdev··on The 'Great Resignation' is really the 'Great Discontent'
My employer administered questions regarding how many days per week the employees wanted to spend in-office versus WFH.

Zero days per week in the office was not presented as an option.

slumdev··on How to Hack APIs in 2021
Exactly.

A flawless SPA backed by a flawless API that produces responses in tens of milliseconds is superior to the old ways.

But a trash SPA backed by an API that produces responses eventually if ever and requires me to open the browser's developer tools to find out what happened? You can keep it. Old-school frameset sites are better than that.

slumdev··on BioNTech alone could lift German economy by 0.5% this year
Martin, is that you?
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