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rpmisms

3,662 karma · joined August 1, 2019

Bill Mitchell (@protonmail), I build distributed systems and ride dirtbikes.
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rpmisms··on Microsoft killed FoxPro in 2007. Anyway, here's FoxPro revived
Ugh. My first job was rewriting foxpro. Bad memories.
rpmisms··on Ask HN: What default model do you use and why?
Gemini is the least stupid/most neurotypical model family IMHO. Works great for me
rpmisms··on iPhone Duo
100% business gun.
rpmisms··on Y Combinator's Ankit Gupta faces backlash over H-1B comments
Always nice to know how someone really feels about a country that has made them very rich.
rpmisms··on Stripe will reportedly acquire OpenRouter for $7B+
I'm friends with a payment docs writer. Holy crap are payments complicated.
rpmisms··on Stripe will reportedly acquire OpenRouter for $7B+
Yes, Stripe is extremely good at what they do. Payments are complicated.
rpmisms··on Dubious research tied to Red Bull has shaped energy drink policy
Crown and Red Bull (tastes better) is my order if I want to drink and dance.
rpmisms··on The deadly rise of giant trucks and SUVs
Blah. It's a regulation problem. Allow powerful trucks to be small again and they will. Perverse incentives are a bitch.
rpmisms··on We Think the SpaceX IPO Is Overvalued
Doesn't really matter. Elon just has a good track record of delivering value for investors, and will move mountains to make it happen.
rpmisms··on We Think the SpaceX IPO Is Overvalued
I'm generally going to avoid betting against Elon.
rpmisms··on Project Hail Mary – Stellar Navigation Chart
Fantasizing about saving the universe is a good thing, actually.
rpmisms··on Project Hail Mary – Stellar Navigation Chart
Star Trek (TNG onwards) gets this right.
rpmisms··on Project Hail Mary – Stellar Navigation Chart
White people doing anything good is actually bad. Duh.

/s, but I think I'm accurately describing the viewpoint you're responding to.

rpmisms··on Starship's Twelfth Flight Test
Historically, that has been true about rockets.
rpmisms··on Starship's Twelfth Flight Test
Have you met hardware guys? This is not how they operate, in my experience.
rpmisms··on Kimi K2.6 just beat Claude, GPT-5.5, and Gemini in a coding challenge
Sounds incredibly simple to me. One-shot.
rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
You can absolutely avoid glyphosate in your diet. This is obviously some sort of emotional issue for you.
rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
Call it (pun intended) a smell test. I have cited a study that shows biomarkers of gut inflammation strongly correlated with glyphosate exposure. Perhaps you should have read it.

I have raised a flag. Lowering your exposure to a novel chemical agent that directly impacts a massive and poorly-understood symbiotic system within the body isn't a bad response. Glyphosate exposure certainly isn't beneficial, so I'll treat it like Pascal's wager: avoiding this has more upside than downside.

rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
Can you attack the methodology or data instead of the author?
rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
Maybe you should see if you adjust to the bran flakes, cut them out if you don't improve, and see if there's a difference? All sorts of things can disrupt gut biomes, and I think ancestral diets are an interesting area of study. Gut inflammation is absolutely rampant.
rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
I'm not trying to make a complete argument, I'm trying to raise a flag. This issue is not well-studied and has very large corporate sponsors who would like to keep selling Roundup-Ready™ crops. One particular measurable function is inhibition of the shikamate pathway in many different bacteria (the majority of the volume of your gut flora is affected).

Here's a decent paper that shows an adverse effect: https://pmc.ncbi.nlm.nih.gov/articles/PMC10330715/

I understand that this is the realm of crunchy weirdos, but thinking holistically doesn't mean you need to lobotomize yourself.

Here's another paper examining some brain effects of chronic gut inflammation, which could be reasonably inferred as a potential consequence of long-term glyphosate exposure: https://pmc.ncbi.nlm.nih.gov/articles/PMC10661239/

rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
Well, I didn't intend that as a conversation-ender, but it is true. This particular substance inhibits a particular function of certain gut flora that seems important. I think it's safe to call that significant.
rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
Here's a decent one: 13% of the UK reports gluten intolerance symptoms, and only 7% of Germany does. The UK allows pre-harvest glyphosate desiccation, Germany doesn't. I would be happy to bet that the trend continues past my quick Google search.
rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
We know that it's really important to neurological function, which is enough reason to be careful.
rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
The mechanism of action of glyphosate inhibits several important amino acid production processes in the gut. I'm simplifying here, but not having glyphosate in the food supply would be a good thing for the gut, and the science agrees on this.

Glyphosate for field prep also doesn't really come through in food, it's much worse with the pre-harvest desiccation.

rpmisms··on Supreme Court to hear arguments in landmark Roundup weedkiller case
The best-reasoned criticism of glyphosate is that it disrupts the gut biome (this is a fact). I suspect that many "gluten allergies" are actually gut biome problems from glyphosate-desiccated wheat.
rpmisms··on Incident with multple GitHub services
That really does put it in perspective. Wow.
rpmisms··on The dangers of California's legislation to censor 3D printing
Yawn. We're a remarkably peaceful country. We should kill more of our criminals, though.
rpmisms··on The dangers of California's legislation to censor 3D printing
As an unabashed American, guns are amazing and an insanely important part of our national culture. Any attempt to diminish this is an attack on the culture of America. We are a nation of dangerous freedoms and matching individual responsibility. In order to maintain a functional country without ruining what makes America special, we need to simply actually enforce laws and I'll take apart in making our national culture one to be proud of again.

I have been watching footage from the Apollo programs recently, and while the types of people who made that possible are very much still around, we need to encourage that sort of thinking once again. Dangerous freedoms, radical Liberty, complete responsibility.

rpmisms··on The dangers of California's legislation to censor 3D printing
Yeah, no. I have shot 3D printed firearms with the head of the FPC, the most active gun lobby organization in the country.
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