My first job was at a large consumer electronics company, where I would ask for component quotes up to 10million/year, and not get laughed at... I'm now at a smaller SDR house, where 2k/year is pretty good volume. The level of customer support from the vendors and distributors is significantly different now, and not in a good direction.
We've also run into the "Sorry, we can't sell you those parts" a few times, so it's a for real thing.