reedf1

Style and design are relevant to both hackers and startups. Wes Anderson certainly fits the profile... If you are ignorant of design trend setters your are a sitting duck.

Not sure about Fortran - but C for sure, yes.

Use PDM with the UV backend - this accomplishes this in a much more lightweight and performant way.

I take it mostly as an anti-pyretic (fever reducer). For which it is extremely effective. It's my drug of choice for colds, flu, etc.

Why represent my point like that? "is required to change startup culture in Europe." If you don't want it, don't change.

A bottom up cultural shift is required to change startup culture in Europe. I have lived in both the USA and UK, attempted various startups in both. Reactions of family in UK and around Europe - I've given up a simple life to be a chancer, small setbacks are seen as enormous failures, every discussion is commiseration, enormous skepticism. USA friends and family are universally positive, respectful, full-throated and full-hearted behind what I've done, they view my goals as meaningful despite failures. This starts at the bottom and bubbles up to media, investors, company and government.

I would love to get into some game design - and something like this seems intuitive enough from my perspective as a software engineer. Forgive me if this is a naive question, but is the use case for this single-player games or multiplayer games?

Globally last year there were an estimated 1.4 Billion tourist arrivals. Besides the rare baggage issue (which has always been resolved for me within 24 hours), the systems are astoundingly robust. This is likely because these system have been battle tested for decades - and there is a manual resolution for all problem paths and individual staff have significant autonomy.

Passport, credit card, cash - that's all you truly need. No need to stress.

I can afford a personal burrito taxi - but I rent a tiny one bed for 40% of my salary and starting a family seems out of reach with childcare costs at £3k/mo. The older generations - having landed themselves, became treatlers. Their entire political philosophy is cheap treats. While cheap crap, knick-knacks, fast food and all-inclusive vacations have gotten cheaper; the real meaningful parts of life have drifted out of reach.

This is sad to hear, <= 4 hours before bed is the only window of my day for exercise. I can make an effort for the morning but I would need to radically rearrange my life.

If there is not a human-explainable reason a model has made a prediction - and it's just a statistical blob in multi-dimensional feature space (which we cannot introspect) perceived improvement over humans is simply overfitting. It will be extremely good at finding the median issue, or following a decision tree in a more exacting way than a human. What a human can do is expand the degrees of freedom of their internal model at-will, integrate out of sample data, and have a natural human-bias to the individual at the expense of the median. I'd rather have that...

Yes exactly - and more broadly pretty much all food consumed globally is automatically selected by tolerance of storage + packaging + shipping. Many varietals and whole specimens have been lost to the annals of history because they cannot make it to a Walmart in North America from Mato Grosso in a scalable (and profitable) way.

Bananas, for example, are practically a miracle fruit for scalable production and distribution. They are incredibly consistent - have resilient skins, have lots of structure that prevents damage from packing, come in easily managed bunches, and (if temperature controlled) the ripening process can begin on demand at point of delivery.

I do not understand why you feel entitled to the domain. If I was entitled to the domain of every side project I had, I would be a multimillionaire in domain assets.

Middle class does not translate across the atlantic. Middle in the UK might be what an American calls upper. Upper class in the UK is reserved for royalty.

    Participants were instructed to maintain their current 
    dietary habits and physical activity levels for the 
    duration of the study.

My understanding is that creatine increases the amount of available energy for muscles to use (hence increases sports performance, training performance, and recovery) - not increase muscle growth alone. That said - it is an interesting study which helps decompose the effect, this shows that creatine likely provides no other additional benefits.

Even writing articles on this stuff feels like insecurity. Just let the AI fad come and go; the real engineers will take what works and everyone else will fail. The tide goes in - the tide goes out.

I think the problem is largely the enormous wealth extraction from the working class (this includes any working person, including high-tech and finance workers) to the old asset-owning class. Property prices (and rents) and income taxes are setup in such a way to effectively drain you of any potential wealth accrual. You simply cannot reach escape velocity in almost any job.

If you are a high-earning knowledge worker - you will be taxed to the pips, pay some of the highest OECD childcare costs, pay >= 35% of your paycheck in rent alone. The median house to median earnings ratio in even second cities like Manchester, Leeds and Newcastle are comparable to San Francisco. The older generation living an index linked lifestyle are completely immune to seeing these effects.

I've lived in the US too - there is a huge cultural difference in how house prices are treated. Even home owners bemoan high house prices, because they increase their property taxes. This is a huge cultural blind spot in the UK. And a similar system would be enormously helpful (but not exhaustive) in terms of incentives.

We are comparing guns and bullets. The fact that you can genetically engineer a pathogen vector to deliver a gene drive is not well known to the public.

Which replication? Of the virus or of gen 0?

I apologies for my other reply - which was flagged - perhaps I was rude. You are wrong because there are ways to introduce a gene drive through pathogens - e.g. you introduce a self-generating CRISPR payload through a pathogen vector for which it is possible to completely saturate gen 0. Source: I worked in a leading biology lab, with biologists actually performing this research.

I encourage all to look up what a gene drive is - find replace all mentions of 'mosquito' with 'human'. This makes a nuclear bomb look positively provincial - all it would take is one disgruntled post-doc. Only by the grace of god...

How does this differ from Chalice? Or is it a replacement now that it is being deprecated?

Did you know that most people outside the US do not intuitively understand the arbitrary US delineations for North, South, West, Midwest? And yet, "they expect everyone to know they are talking specifically about..."

As a data engineering dabbler; parquet in S3 is beautiful. So is DuckDB. What an incredible match.

If you can detect EBS failure better than Amazon - I'd be selling this to them tomorrow.

I read 10-20 books a year - but I think this obsession with book reading is excessively chauvinistic. If the benefit of reading is consuming complex long form stories, don't we get that from long-running TV series, audiobooks, visual novels, videogames, manga? If the answer to that is NO - then the benefit is the mechanical act of reading text? Well we do that on social media, news, group chats.

I do not see how it is possible that the benefit of reading a book has not been subsumed by all of the content we manage to absorb in modern media.

I actually agree - it's part incentives. And it is important for hard sciences to learn these lessons as well.

Statistics are not values you collect - but the analysis you perform. In data with many confounding variables or many degrees of freedom, the only way to be honest about what the data shows is through statistics. Statistics is what allows you to filter signal from noise. Statistical significance is a very useful tool, you just have to be honest about what it represents and under what conditions this breaks down.

Many scientists in non-mathematical fields are wrote taught "how to write a paper" in undergrad. P-values and statistical significance are taught completely devoid of context, essentially just a step in your final analysis. Many scientists perpetrating p-hacking or data dredging thought this was a process of good science, and didn't understand the axioms for which these metrics depend. This is something learning fixes, and ignorance makes worse.